| Gene Symbol |
EIF3G
|
| Entrez Gene |
8666
|
| Alt Symbol |
EIF3-P42, EIF3S4, eIF3-delta, eIF3-p44
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
eukaryotic translation initiation factor 3, subunit G
|
| Other Description |
eIF-3 RNA-binding subunit|eIF-3-delta|eIF3 p42|eIF3 p44|eukaryotic translation initiation factor 3 RNA-binding subunit|eukaryotic translation initiation factor 3 subunit 4|eukaryotic translation initiation factor 3 subunit G|eukaryotic translation initiation factor 3 subunit p42|eukaryotic translation initiation factor 3, subunit 4 (delta, 44kD)|eukaryotic translation initiation factor 3, subunit 4 delta, 44kDa
|
| Swissprots |
O14801 O75821 Q969U5
|
| Accessions |
AAG15396 EAW84078 O75821 AA134976 AF020833 AAB71866 AF094850 AAG15419 AK291320 BAF84009 AK293374 BAH11496 AK296377 BAG59051 AK309944 AK311624 AK315896 BAF98787 AK316040 BAH14411 AK316335 BAH14706 BC000733 AAH00733 BC008469 AAH08469 BE017996 BF701069 BT006889 AAP35535 CR457134 CAG33415 DQ890616 ABM92233 DQ896801 ABM87800 U96074 AAC78728 NM_003755 NP_003746
|
| Function |
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA.
|
| Subcellular Location |
Cytoplasm {ECO:0000255|HAMAP-Rule:MF_03006}. Nucleus {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17094969}. Cytoplasm, perinuclear region {ECO:0000255|HAMAP-Rule:MF_03006, ECO:0000269|PubMed:17094969}. Note=Colocalizes with AIFM1 in the nucleus and perinuclear region.
|
| Top Pathways |
RNA transport
|