| Gene Symbol | Tnc |
|---|---|
| Entrez Gene | 21923 |
| Alt Symbol | AI528729, C130033P17Rik, Hxb, TN, TN-C, Ten, cytotactin, tenascin-C |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | tenascin C |
| Other Description | hexabrachion|tenascin|tnc |
| Swissprots | Q80YX1 Q80YX2 Q64706 |
| Accessions | EDL31088 EDL31089 Q80YX1 AJ236880 CAB44238 AK040167 BAC30529 AK048765 AK085667 BC117979 AAI17980 BC117980 AAI17981 BU614130 BY300535 CB521403 CD352874 CF531007 CN664449 CN692948 CX568603 D90343 BAA14355 X56304 CAA39751 X80281 XM_006537774 XP_006537837 XM_006537775 XP_006537838 XM_006537776 XP_006537839 XM_006537777 XP_006537840 NM_011607 NP_035737 |
| Function | Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth when provided to neurons in culture. May play a role in supporting the growth of epithelial tumors. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. {ECO:0000250|UniProtKB:P24821, ECO:0000269|PubMed:16553788}. |
| Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
| Tissue Specificity | High levels of isoform 2 in lung and brain of newborn mice. High levels of isoform 5 in thymus, moderate levels in brain of newborn and adult mice. Low level of isoform 2 in adult brain. {ECO:0000269|PubMed:1717349}. |
| Top Pathways | Focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway, MicroRNAs in cancer |