| Gene Symbol |
PHF20
|
| Entrez Gene |
51230
|
| Alt Symbol |
C20orf104, GLEA2, HCA58, NZF, TDRD20A, TZP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
PHD finger protein 20
|
| Other Description |
glioma-expressed antigen 2|hepatocellular carcinoma-associated antigen 58|novel zinc finger protein|transcription factor TZP|tudor domain containing 20A
|
| Swissprots |
Q9H4J6 Q9BXA3 Q9BWV4 E1P5S3 Q9H421 Q66K49 Q5JWY9 Q9BVI0 Q566Q2 Q9BZW3 A7E235 Q9NZ22 B2RB56
|
| Accessions |
EAW76153 EAW76154 EAW76155 EAW76156 EAW76157 EAW76158 Q9BVI0 AF220416 AAF34184 AF258787 AAG49888 AF348207 AAK19748 AK054597 AK090798 AK097498 BAG53476 AK314503 BAG37103 AL137330 AL558423 AY027523 AAK13046 AY134747 AAN08621 BC006415 BC015538 BC016948 BC022933 BC048210 AAH48210 BC062681 BC080598 AAH80598 BC093405 AAH93405 BC150178 AAI50179 BG778940 BM906582 BX643875 CD690482 DQ599920 L09749 XM_005260421 XP_005260478 XM_011528842 XP_011527144 XM_011528843 XP_011527145 XM_011528844 XP_011527146 XM_011528845 XP_011527147 XM_011528846 XP_011527148 XM_011528847 XP_011527149 XM_011528848 XP_011527150 NM_016436 NP_057520
|
| Function |
Methyllysine-binding protein, component of the MOF histone acetyltransferase protein complex. Not required for maintaining the global histone H4 'Lys-16' acetylation (H4K16ac) levels or locus specific histone acetylation, but instead works downstream in transcriptional regulation of MOF target genes (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. Contributes to methyllysine-dependent p53/TP53 stabilization and up-regulation after DNA damage. {ECO:0000250, ECO:0000269|PubMed:20018852, ECO:0000269|PubMed:22864287}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:20018852}.
|
| Tissue Specificity |
Expressed in heart, kidney, liver, lung, pancreas, placenta, spleen and testis. Not expressed in brain, skeletal muscle, colon, ovary, prostate, small intestine and thymus. Expressed in colon and ovary cancer cell lines while it is not expressed in the respective normal tissues. {ECO:0000269|PubMed:12097419}.
|