| Gene Symbol |
ANKHD1
|
| Entrez Gene |
54882
|
| Alt Symbol |
MASK, MASK1, PP2500, VBARP
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ankyrin repeat and KH domain containing 1
|
| Other Description |
HIV-1 Vpr-binding ankyrin repeat protein|ankyrin repeat and KH domain-containing protein 1|multiple ankyrin repeats, single KH-domain homolog
|
| Swissprots |
Q9HA95 Q149P2 A6NH85 Q9NWG4 Q8WY90 Q8IWZ3 Q9UPR7 Q96GK0 Q9H2U0 Q8IWZ2 Q96G77
|
| Accessions |
EAW62057 EAW62058 EAW62059 Q8IWZ3 AF217646 AAG41779 AF258557 AAG23760 AF521882 AAO14943 AI675547 AI870943 AK000295 BAA91063 AK000904 BAA91417 AK022041 BAB13958 AK022433 AK024056 AK024189 BAB14849 AK074173 BAB84999 AK098574 AL136943 CAB66877 AY070436 AAL65263 BC004457 AAH04457 BC009420 AAH09420 BC009909 AAH09909 BC040231 AAH40231 BC117677 AAI17678 BC117678 AAI17679 BC127127 AAI27128 BC150486 AAI50487 BC172415 AAI72415 DA509209 JF432842 ADZ16059 NM_001197030 NP_001183959 NM_017747 NP_060217 NM_017978 NP_060448 NM_024668 NP_078944
|
| Function |
May play a role as a scaffolding protein that may be associated with the abnormal phenotype of leukemia cells. Isoform 2 may possess an antiapoptotic effect and protect cells during normal cell survival through its regulation of caspases. {ECO:0000269|PubMed:16098192}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:16098192, ECO:0000269|PubMed:16956752}.
|
| Tissue Specificity |
Ubiquitous with high expression in cervix, spleen and brain. Expressed in hematopoietic cells with increased expression in leukemia cells. Isoform 2 is highly expressed in spleen with almost no expression in muscle and brain. {ECO:0000269|PubMed:14557257, ECO:0000269|PubMed:16098192, ECO:0000269|PubMed:16956752}.
|