Gene Symbol | MED20 |
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Entrez Gene | 9477 |
Alt Symbol | PRO0213, TRFP |
Species | Human |
Gene Type | protein-coding |
Description | mediator complex subunit 20 |
Other Description | Trf (TATA binding protein-related factor)-proximal homolog|mediator of RNA polymerase II transcription subunit 20 |
Swissprots | Q9Y429 O95821 Q5T8J4 B4DE08 Q9H944 |
Accessions | EAX04067 EAX04068 Q9H944 AF097725 AAD16169 AF116602 AAF71027 AJ420544 AK023092 BAB14399 AK097385 BAG53461 AK293412 BAG56919 AK300573 BAG62275 AK307070 AL050196 CAB43314 BC012618 AAH12618 BC015189 BC019866 AAH19866 BC032552 AAH32552 BC033498 BC040950 AAH40950 BC063509 BU597139 DA909832 EU446931 ABZ92460 NM_001305455 NP_001292384 NM_001305456 NP_001292385 NM_001305457 NP_001292386 NM_004275 NP_004266 NR_131160 |
Function | Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. |
Subcellular Location | Nucleus {ECO:0000305}. |
TRFP CRISPR/Cas9 KO Plasmid (h) - sc-410553 from Santa Cruz Biotechnology
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TRFP HDR Plasmid (h) - sc-410553-HDR from Santa Cruz Biotechnology
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TRFP Double Nickase Plasmid (h) - sc-410553-NIC from Santa Cruz Biotechnology
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TRFP Double Nickase Plasmid (h2) - sc-410553-NIC-2 from Santa Cruz Biotechnology
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TRFP CRISPR Activation Plasmid (h) - sc-410553-ACT from Santa Cruz Biotechnology
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TRFP CRISPR Activation Plasmid (h2) - sc-410553-ACT-2 from Santa Cruz Biotechnology
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TRFP Lentiviral Activation Particles (h) - sc-410553-LAC from Santa Cruz Biotechnology
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TRFP Lentiviral Activation Particles (h2) - sc-410553-LAC-2 from Santa Cruz Biotechnology
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TRFP siRNA (h) - sc-38598 from Santa Cruz Biotechnology
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TRFP shRNA Plasmid (h) - sc-38598-SH from Santa Cruz Biotechnology
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TRFP shRNA (h) Lentiviral Particles - sc-38598-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU068561 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13169 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13169 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10229 from Sigma-Aldrich
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MED20 siRNA (Human) - CRH6292 from Cohesion Biosciences
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MED20 RNAi - H00009477-R01 from Novus Biologicals
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shRNA set against Human MED20 (NM_004275.3) - SHH339975 from Creative biogene
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shRNA set against Human TRFP(NM_004275.3) - SHH223674 from Creative biogene
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Human MED20 siRNA - orb266794 from Biorbyt
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MED20 shRNA Plasmid (Human) - CHH6292 from Cohesion Biosciences
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MED20 miRNA 3'UTR clone - MiUTR1H-10708 from Creative biogene
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