| Gene Symbol | Creb3l1 |
|---|---|
| Entrez Gene | 362165 |
| Alt Symbol | Oasis |
| Species | Rat |
| Gene Type | protein-coding |
| Description | cAMP responsive element binding protein 3-like 1 |
| Other Description | cAMP-responsive element-binding protein 3-like protein 1|cyclic AMP-responsive element-binding protein 3-like protein 1|old astrocyte specifically-induced substance |
| Swissprots | Q66HA2 |
| Accessions | EDL79555 EDL79556 Q66HA2 BC081951 AAH81951 XM_006234584 XP_006234646 NM_001005562 NP_001005562 |
| Function | Transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. Specifically involved in ER-stress response in astrocytes in the central nervous system. May play a role in gliosis. In vitro, binds to box-B element, cAMP response element (CRE) and CRE-like sequences, and activates transcription through box-B element but not through CRE (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Top Pathways | cGMP-PKG signaling pathway, Huntington's disease, Glucagon signaling pathway, Prostate cancer, PI3K-Akt signaling pathway |