| Gene Symbol | INHA |
|---|---|
| Entrez Gene | 3623 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | inhibin, alpha |
| Other Description | A-inhibin subunit|inhibin alpha chain |
| Swissprots | P05111 A8K8H5 |
| Accessions | ACI28454 CAA01158 CAA28040 EAW70774 P05111 AW025787 BC006391 AAH06391 BC039076 BT006954 AAP35600 DQ890602 ABM92219 DQ893773 ABM84699 M13144 AAA59167 M13981 AAA59166 NM_002191 NP_002182 |
| Function | Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Originally found in ovary (granulosa cells) and testis (Sertoli cells), but widely distributed in many tissues including brain and placenta. In adrenal cortex expression is limited to the zona reticularis and the innermost zona fasciculata in the normal gland, extending centripetally into the zona fasciculata in hyperplasia. Also found in adrenocortical tumors. Also expressed in prostate epithelium of benign prostatic hyperplasia, in regions of basal cell hyperplasia and in nonmalignant regions of high grade prostate cancer. Only circulating inhibin B is found in male, whereas circulating inhibins A and B are found in female. {ECO:0000269|PubMed:9506758}. |