| Gene Symbol |
ZFP90
|
| Entrez Gene |
146198
|
| Alt Symbol |
FIK, NK10, ZNF756, zfp-90
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ZFP90 zinc finger protein
|
| Other Description |
FOXP3-interacting KRAB domain-containing protein|zinc finger protein 476|zinc finger protein 756|zinc finger protein 90 homolog
|
| Swissprots |
L7S2P3 Q96MQ6 Q49AD1 B3KVE7 B2RU00 Q8TF47
|
| Accessions |
EAW83234 EAW83235 Q8TF47 AA236523 AB075834 BAB85540 AK056596 BAB71228 AK074332 AK122847 BAG53759 AK123121 AK126167 BAC86467 AK304152 BAG65042 AK316251 BAH14622 AW135652 BC033165 AAH33165 BC040486 BC040871 BC140886 AAI40887 BC140887 AAI40888 DA803284 KC249978 AGC13464 XM_005255802 XP_005255859 XM_005255803 XP_005255860 XM_005255804 XP_005255861 XM_005255805 XP_005255862 XM_011522873 XP_011521175 NM_001305203 NP_001292132 NM_001305204 NP_001292133 NM_001305206 NP_001292135 NM_001305207 NP_001292136 NM_001305208 NP_001292137 NM_133458 NP_597715 NR_130976 NR_130977 NR_130978
|
| Function |
May function as a repressor or silencer protein, and most likely exerts its repressing activity upon zinc-dependent binding to DNA. May be involved in proper spermatogenesis by repressing the expression of genes unnecessary or incompatible with the maintenance of a haploid cell state (By similarity). Isoform 2 acts as a bridge between FOXP3 and the corepressor TRIM28, and is required for the transcriptional repressor activity of FOXP3 in regulatory T-cells (Treg) (PubMed:23543754). {ECO:0000250|UniProtKB:Q61967, ECO:0000269|PubMed:23543754}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Tissue Specificity |
Isoform 2 is highly expressed in the regulatory T-cells (Treg). {ECO:0000269|PubMed:23543754}.
|