| Gene Symbol |
Wipi2
|
| Entrez Gene |
74781
|
| Alt Symbol |
1110018O08Rik, 2510001I10Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
WD repeat domain, phosphoinositide interacting 2
|
| Other Description |
WD repeat domain phosphoinositide-interacting protein 2|WIPI-2
|
| Swissprots |
Q80W47
|
| Accessions |
EDL19090 EDL19091 EDL19092 Q80W47 AK003796 AK010881 AK041989 AK043857 AK045824 AK079281 AK155113 BAE33057 AK169051 BAE40839 AK172030 BAE42786 AK194559 AK213114 BC019549 BC038018 BC044894 AAH44894 BC060262 XM_006504752 XP_006504815 NM_178398 NP_848485
|
| Function |
Early component of the autophagy machinery being involved in formation of preautophagosomal structures and their maturation into mature phagosomes in response to phosphatidylinositol 3-phosphate (PtdIns3P). Recruits the ATG12- ATG5-ATG16L1 complex to omegasomes, resulting in ATG8 family proteins lipidation and starvation-induced autophagy. Omegasomes are derived from ER and serve as intermediates for genesis of isolation membrane (also called preautophagosome) from ER cisternae membranes. {ECO:0000269|PubMed:23051912, ECO:0000269|PubMed:23291478, ECO:0000269|PubMed:24954904}.
|
| Subcellular Location |
Preautophagosomal structure membrane {ECO:0000269|PubMed:23051912, ECO:0000269|PubMed:23291478, ECO:0000269|PubMed:24954904}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q9Y4P8}; Cytoplasmic side {ECO:0000250|UniProtKB:Q9Y4P8}. Note=Enriched at preautophagosomal structure membranes in response to PtdIns3P. Dissociates from mature phagosome membranes. {ECO:0000250|UniProtKB:Q9Y4P8}.
|