GGT1

Gene Symbol GGT1
Entrez Gene 2678
Alt Symbol CD224, D22S672, D22S732, GGT, GGT 1, GTG
Species Human
Gene Type protein-coding
Description gamma-glutamyltransferase 1
Other Description gamma-glutamyltranspeptidase 1|glutathione hydrolase 1|leukotriene-C4 hydrolase
Swissprots Q08247 Q14404 Q9UMK1 P19440 Q8TBS1
Accessions CAA07266 CAA07485 CAA07486 CAA07487 CAA07536 P19440 AL832738 AU077341 BC025927 AAH25927 BC035341 BC065921 AAH65921 BC069326 AAH69326 BC069473 AAH69473 BC069504 AAH69504 BC128234 AAI28235 BC128238 AAI28239 BC128239 AAI28240 BM673976 BU157907 BU164348 CD625024 CR456494 CAG30380 CU013091 CAK54522 CU013379 CAK54821 DQ000492 DQ893412 ABM84338 DQ895950 ABM86876 HY003521 J04131 AAA52547 J05235 AAA35889 L20490 AAA02884 L20493 AAA02886 L20494 AAA02887 M24087 AAA35899 M24903 AAA52546 X60069 CAA42674 NM_013421 NP_038265 NM_013430 NP_038347 NM_001032364 NM_001032365 NM_005265 NM_001288833 NP_001275762
Function Cleaves the gamma-glutamyl bond of extracellular glutathione (gamma-Glu-Cys-Gly), glutathione conjugates, and other gamma-glutamyl compounds. The metabolism of glutathione releases free glutamate and the dipeptide, cysteinyl-glycine, which is hydrolyzed to cysteine and glycine by dipeptidases. In the presence of high concentrations of dipeptides and some amino acids, can also catalyze a transpeptidation reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound. Initiates extracellular glutathione (GSH) breakdown, provides cells with a local cysteine supply and contributes to maintain intracellular GSH level. It is part of the cell antioxidant defense mechanism. Isoform 3 seems to be inactive. {ECO:0000269|PubMed:20622017, ECO:0000269|PubMed:24047895, ECO:0000269|PubMed:7673200, ECO:0000269|PubMed:7759490, ECO:0000269|PubMed:8095045, ECO:0000269|PubMed:8827453}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23682772, ECO:0000269|PubMed:8095045}; Single-pass type II membrane protein {ECO:0000269|PubMed:23682772, ECO:0000269|PubMed:8095045}.
Tissue Specificity Detected in fetal and adult kidney and liver, adult pancreas, stomach, intestine, placenta and lung. Isoform 3 is lung-specific. There are several other tissue-specific forms that arise from alternative promoter usage but that produce the same protein.
Top Pathways Taurine and hypotaurine metabolism, Glutathione metabolism, Arachidonic acid metabolism, Cyanoamino acid metabolism

GGT1 (E-5) - sc-166908 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GGT1 (E-5): sc-166908. Western blot analysis of GGT1 expression in Hep G2 whole cell lysate.

GGT1 (H-205) - sc-20638 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

GGT1 (3E6) - sc-100746 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
GGT1 (3E6): sc-100746. Western blot analysis of GGT1 expression in NIH/3T3 whole cell lysate.

GGT1/2 (A-14) - sc-23823 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
GGT1/2 (A-14): sc-23823. Western blot analysis of GGTLC1 expression in non-transfected 293T: sc-117752 (A), human GGTLC1 transfected 293T: sc-115900 (B) and Hep G2 (C) whole cell lysates.

GGT1/2 (A-4) - sc-393706 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
GGT1/2 (A-4): sc-393706. Western blot analysis of GGT1/2 expression in Hep G2 whole cell lysate (A) and mouse kidney (B) and human kidney (C) tissue extracts.

GGT1/2 (V-20) - sc-19795 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

GGT1/2 (H-170) - sc-20639 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

Anti-GGT1 antibody - ab55138 from Abcam

Prices $394.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
GGT1 antibody (ab55138) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human testis.

Anti-GGT1 antibody - ab175384 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-GGT1 antibody (ab175384) at 1/500 dilution + A549 cell extract

Anti-GGT1 antibody - ab96466 from Abcam

Prices $359.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-GGT1 antibody (ab96466) at 1/500 dilution + MOLT4 whole cell lysate at 30 µg

Anti-GGT1 antibody - ab172040 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-GGT1 antibody (ab172040) at 1/1 dilutionLane 1 : GGT1 transfected 293T cell line lysateLane 2 : Non-transfected 293T cell line lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Rabbit IgG (H+L), Peroxidase Conjugated at 1/7500 dilution

Anti-GGT1 antibody - ab174680 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-GGT1 antibody (ab174680) at 0.300000011921 µg/ml + Human kidney tissue lysate in RIPA buffer at 35 µgSecondaryRabbit anti-goat HRP conjugated antibody at 1/20000 dilutiondeveloped using the ECL technique

Anti-GGT1 antibody - ab174753 from Abcam

Prices $376.00
Sizes 200 µl
Host Goat
Clonality Polyclonal
Anti-GGT1 antibody (ab174753) at 0.1 µg/ml + Human kidney tissue lysate in RIPA buffer at 35 µgdeveloped using the ECL technique

Anti-GGT1 antibody [138H11] - ab140327 from Abcam

Prices $379.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 138H11
Immunohistochemical analysis of paraffin embedded Human tonsil tissue labelling GGT1 using ab140327.

Anti-GGT1 antibody [1F9] - ab117571 from Abcam

Prices $378.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 1F9
Immunohistochemical analysis of GGT1 expression in Formalin-Fixed, Paraffin-Embedded Human Kidney, Tubules, using 5 µg/ml ab117571.

Anti-GGT1 antibody [EPR5288] - ab109427 from Abcam

Prices $381.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR5288
All lanes : Anti-GGT1 antibody [EPR5288] (ab109427) at 1/1000 dilutionLane 1 : Fetal liver lysateLane 2 : HepG2 cell lysateLane 3 : Fetal kidney lysateLane 4 : A549 cell lysateLysates/proteins at 10 µg per lane.

Anti-GGT1 antibody - N-terminal - ab195662 from Abcam

Prices $376.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-GGT1 antibody - N-terminal (ab195662) at 0.3 µg/ml + human kidney lysate in RIPA buffer at 35 µg

Anti-GGT1 / GGT Antibody (clone 138H11) - LS-C23900 from LifeSpan Bioscience

Prices $475.00
Sizes 500 µl
Host Mouse
Clonality Monoclonal
Clone 138H11

Anti-GGT1 / GGT Antibody (aa1-569) - LS-C143880 from LifeSpan Bioscience

Prices $475.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-GGT1 / GGT Antibody (clone 138H11, Azide-free) - LS-C23901 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 138H11

Anti-GGT1 / GGT Antibody (clone SPM398) - LS-C33907 from LifeSpan Bioscience

Prices $305.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone SPM398
Human tonsil stained with anti-gamma glutamyl transferase

Anti-GGT1 / GGT Antibody (aa12-39, AP) - LS-C214691 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGT1 / GGT Antibody (aa12-39, APC) - LS-C214690 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGT1 / GGT Antibody (aa12-39, Biotin) - LS-C214692 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-GGT1 / GGT Antibody (aa12-39, FITC) - LS-C214693 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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