| Gene Symbol | Fib |
|---|---|
| Entrez Gene | 37662 |
| Alt Symbol | CG9888, Dmel\CG9888, Fibri, GCR-6, GCR6, Pen59C5, fib, pen59C5 |
| Species | Drosophila |
| Gene Type | protein-coding |
| Description | Fibrillarin |
| Other Description | CG9888-PA|Fib-PA|fibrillarin |
| Swissprots | Q8IGK5 Q24348 Q9W1V3 |
| Accessions | AAF46950 Q9W1V3 BT125830 ADR83715 NM_079093 NP_523817 |
| Function | S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L- methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus, nucleolus {ECO:0000250}. Note=Fibrillar region of the nucleolus. {ECO:0000250}. |
| Top Pathways | Ribosome biogenesis in eukaryotes |
Recombinant Drosophila melanogaster rRNA 2'-O-methyltransferase fibrillarin(Fib - CSB-YP892929DLU CSB-EP892929DLU CSB-BP892929DLU CSB-MP892929DLU from Cusabio
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rRNA 2'-O-methyltransferase fibrillarin (Fib), Recombinant Protein - MBS1484683 from MyBioSource
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