| Gene Symbol |
RANBP10
|
| Entrez Gene |
57610
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
RAN binding protein 10
|
| Other Description |
ran-binding protein 10
|
| Swissprots |
Q9P264 B4DID0 A4FTY2 B4DQH9 E7EW27 Q6VN20
|
| Accessions |
EAW83167 EAW83168 Q6VN20 AB040897 BAA95988 AK000686 AK055634 AK055727 BAG51561 AK295171 BAG58181 AK295530 BAG58442 AK298806 BAG60941 AK304030 BAG64944 AL137299 AY337313 AAR01220 BC099917 AAH99917 BC121176 AAI21177 BC121177 AAI21178 XM_005256070 XP_005256127 XM_005256072 XP_005256129 XM_006721238 XP_006721301 XM_011523245 XP_011521547 XM_011523246 XP_011521548 XM_011523247 XP_011521549 NM_020850 NP_065901
|
| Function |
Acts as a guanine nucleotide exchange factor (GEF) for RAN GTPase (By similarity). May play an essential role in hemostasis and in maintaining microtubule dynamics with respect to both platelet shape and function (By similarity). May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but does not affect estrogen- induced transactivation. In contrast to RANBP9, does not interact with Sos and does not activate the Ras pathway. {ECO:0000250, ECO:0000269|PubMed:18222118}.
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000269|PubMed:18222118}. Nucleus {ECO:0000269|PubMed:18222118}. Note=Predominantly cytoplasmic.
|
| Tissue Specificity |
Broadly expressed, with highest levels in skeletal muscle. {ECO:0000269|PubMed:14684163}.
|