DMPK

Gene Symbol	DMPK
Entrez Gene	1760
Alt Symbol	DM, DM1, DM1PK, DMK, MDPK, MT-PK
Species	Human
Gene Type	protein-coding
Description	dystrophia myotonica-protein kinase
Other Description	DM protein kinase|DM1 protein kinase|myotonic dystrophy associated protein kinase|myotonin protein kinase A|myotonin-protein kinase|thymopoietin homolog
Swissprots	E5KR08 Q16205 Q6P5Z6 Q09013
Accessions	AAA36205 AAA75235 AAA75236 AAA75237 AAA75238 AAA75239 AAA75240 AAC14448 AAC14449 AAC14450 AAC14451 ADP91334 ADP91335 ADP91336 ADP91337 ADP91338 ADP91339 ADP91340 ADP91341 ADP91342 ADP91343 ADP91344 ADP91345 ADP91346 ADP91347 ADP91348 ADP91349 ADP91350 ADP91351 ADP91352 ADP91353 ADP91354 ADP91355 ADP91356 ADP91357 ADP91358 ADP91359 ADP91360 ADP91361 ADP91362 ADP91363 ADP91364 ADP91365 ADP91366 ADP91367 ADP91368 ADP91369 ADP91370 ADP91371 ADP91372 ADP91373 ADP91374 ADP91375 ADP91376 ADP91377 ADP91378 ADP91379 ADP91380 ADP91381 ADP91382 ADP91383 ADP91384 ADP91385 ADP91386 ADP91387 ADP91388 ADP91389 ADP91390 ADP91391 ADP91392 ADP91393 ADP91394 ADP91395 ADP91396 ADP91397 ADP91398 ADP91399 ADP91400 ADP91401 ADP91402 ADP91403 ADP91404 ADP91405 ADP91406 ADP91407 ADP91408 ADP91409 ADP91410 ADP91411 ADP91412 ADP91413 ADP91414 ADP91415 ADP91416 ADP91417 ADP91418 ADP91419 ADP91420 ADP91421 ADP91422 ADP91423 ADP91424 ADP91425 ADP91426 ADP91427 ADP91428 ADP91429 ADP91430 ADP91431 ADP91432 ADP91433 ADP91434 ADP91435 ADP91436 ADP91437 ADP91438 ADP91439 ADP91440 ADP91441 ADP91442 ADP91443 ADP91444 ADP91445 ADP91446 ADP91447 ADP91448 ADP91449 ADP91450 ADP91451 ADP91452 ADP91453 ADP91454 ADP91455 ADP91456 ADP91457 ADP91458 ADP91459 ADP91460 ADP91461 ADP91462 ADP91463 ADP91464 ADP91465 ADP91466 ADP91467 ADP91468 ADP91469 ADP91470 ADP91471 ADP91472 ADP91473 ADP91474 ADP91475 ADP91476 ADP91477 ADP91478 ADP91479 ADP91480 ADP91481 ADP91482 ADP91483 ADP91484 ADP91485 ADP91486 ADP91487 ADP91488 ADP91489 ADP91490 ADP91491 ADP91492 ADP91493 EAW57380 EAW57381 EAW57382 EAW57383 EAW57384 EAW57385 Q09013 AB209363 BAD92600 AK297299 BAG59767 AK302874 BAG64054 AK304749 BAH14251 AV655848 BC026328 AAH26328 BC062553 AAH62553 BG152972 BG706056 BP422066 BQ670576 DC420602 HY031977 KJ534826 AHW56466 KJ534827 AHW56467 KJ534828 AHW56468 L19268 AAA36206 M87312 M87313 M94203 AAA64884 S72883 AAB31800 S86455 U46546 AAA87583 NM_001081560 NP_001075029 NM_001081562 NP_001075031 NM_001081563 NP_001075032 NM_001288764 NP_001275693 NM_001288765 NP_001275694 NM_001288766 NP_001275695 NM_004409 NP_004400
Function	Non-receptor serine/threonine protein kinase which is necessary for the maintenance of skeletal muscle structure and function. May play a role in myocyte differentiation and survival by regulating the integrity of the nuclear envelope and the expression of muscle-specific genes. May also phosphorylate PPP1R12A and inhibit the myosin phosphatase activity to regulate myosin phosphorylation. Also critical to the modulation of cardiac contractility and to the maintenance of proper cardiac conduction activity probably through the regulation of cellular calcium homeostasis. Phosphorylates PLN, a regulator of calcium pumps and may regulate sarcoplasmic reticulum calcium uptake in myocytes. May also phosphorylate FXYD1/PLM which is able to induce chloride currents. May also play a role in synaptic plasticity. {ECO:0000269|PubMed:10811636, ECO:0000269|PubMed:10913253, ECO:0000269|PubMed:11287000, ECO:0000269|PubMed:15598648, ECO:0000269|PubMed:21457715, ECO:0000269|PubMed:21949239}.
Subcellular Location	Isoform 3: Mitochondrion membrane.
Tissue Specificity	Most isoforms are expressed in many tissues including heart, skeletal muscle, liver and brain, except for isoform 2 which is only found in the heart and skeletal muscle, and isoform 14 which is only found in the brain, with high levels in the striatum, cerebellar cortex and pons. {ECO:0000269|PubMed:7488138}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

DMPK CRISPR/Cas9 KO Plasmid (h) - sc-402727 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DMPK HDR Plasmid (h) - sc-402727-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DMPK Double Nickase Plasmid (h) - sc-402727-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DMPK Double Nickase Plasmid (h2) - sc-402727-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DMPK CRISPR Activation Plasmid (h) - sc-402727-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DMPK CRISPR Activation Plasmid (h2) - sc-402727-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

DMPK Lentiviral Activation Particles (h) - sc-402727-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DMPK Lentiviral Activation Particles (h2) - sc-402727-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

DMPK siRNA (h) - sc-38993 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DMPK shRNA Plasmid (h) - sc-38993-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DMPK shRNA (h) Lentiviral Particles - sc-38993-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

DMPK RNAi - H00001760-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

DMPK RNAi - H00001760-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU099191 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0631 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0630 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0629 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0628 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0627 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0626 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN2216 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2216 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

DMPK siRNA (Human) - CRH1223 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

DMPK - MBS8202645 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human DMPK (NM_004409.3) - SHH278845 from Creative biogene Category siRNA Species Reactivities Human

Search more