NHP6B

Gene Symbol NHP6B
Entrez Gene 852386
Alt Symbol YBR090C-A
Species Yeast
Gene Type protein-coding
Description Nhp6bp
Other Description -
Swissprots P89501 P11633 D6VQ90 A2TBM2 P89500
Accessions DAA07210 P11633 NM_001180058 NP_009647
Function DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex. Required for transcriptional initiation fidelity of some but not all tRNA genes. Seems to be functionally redundant with NHP6A. {ECO:0000269|PubMed:11118215, ECO:0000269|PubMed:11239460, ECO:0000269|PubMed:11287614, ECO:0000269|PubMed:11432837, ECO:0000269|PubMed:12952948, ECO:0000269|PubMed:14585989, ECO:0000269|PubMed:16407207, ECO:0000269|PubMed:7721780, ECO:0000269|PubMed:8946917}.
Subcellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00267, ECO:0000269|PubMed:14562095}. Chromosome {ECO:0000269|PubMed:14562095}.

Search more