| Gene Symbol | Galnt4 |
|---|---|
| Entrez Gene | 14426 |
| Alt Symbol | AV011803 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 |
| Other Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4|galNAc-T4|polypeptide GalNAc transferase 4|polypeptide N-acetylgalactosaminyltransferase 4|pp-GaNTase 4|ppGaNTase-T4|protein-UDP acetylgalactosaminyltransferase 4 |
| Swissprots | O08832 Q3U681 |
| Accessions | EDL21644 O08832 AK033494 BAC28317 AK148036 BAE28303 AK153253 BAE31844 AV080565 BC057882 AAH57882 BP761617 BQ179479 CJ093518 U73819 AAB58301 NM_015737 NP_056552 |
| Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward EA2 peptide substrate and a much lower activity with EPO-T, Muc2, Muc1a, Muc1b. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Highly expressed in sublingual gland, stomach, colon, small intestine and cervix. Expressed at intermediate levels in kidney, ovary, lung and uterus. Weakly expressed in spleen, liver, heart and brain. Not expressed in submandibular and parotid glands, skeletal muscle and testis. {ECO:0000269|PubMed:9153242}. |
| Top Pathways | Mucin type O-Glycan biosynthesis |