Gene Symbol | Galnt4 |
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Entrez Gene | 14426 |
Alt Symbol | AV011803 |
Species | Mouse |
Gene Type | protein-coding |
Description | UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 4 |
Other Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 4|galNAc-T4|polypeptide GalNAc transferase 4|polypeptide N-acetylgalactosaminyltransferase 4|pp-GaNTase 4|ppGaNTase-T4|protein-UDP acetylgalactosaminyltransferase 4 |
Swissprots | O08832 Q3U681 |
Accessions | EDL21644 O08832 AK033494 BAC28317 AK148036 BAE28303 AK153253 BAE31844 AV080565 BC057882 AAH57882 BP761617 BQ179479 CJ093518 U73819 AAB58301 NM_015737 NP_056552 |
Function | Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a highest activity toward EA2 peptide substrate and a much lower activity with EPO-T, Muc2, Muc1a, Muc1b. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Highly expressed in sublingual gland, stomach, colon, small intestine and cervix. Expressed at intermediate levels in kidney, ovary, lung and uterus. Weakly expressed in spleen, liver, heart and brain. Not expressed in submandibular and parotid glands, skeletal muscle and testis. {ECO:0000269|PubMed:9153242}. |
Top Pathways | Mucin type O-Glycan biosynthesis |
GalNAc-T4 CRISPR/Cas9 KO Plasmid (m) - sc-420478 from Santa Cruz Biotechnology
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GalNAc-T4 HDR Plasmid (m) - sc-420478-HDR from Santa Cruz Biotechnology
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GalNAc-T4 Double Nickase Plasmid (m) - sc-420478-NIC from Santa Cruz Biotechnology
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GalNAc-T4 Double Nickase Plasmid (m2) - sc-420478-NIC-2 from Santa Cruz Biotechnology
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GalNAc-T4 CRISPR Activation Plasmid (m) - sc-420478-ACT from Santa Cruz Biotechnology
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GalNAc-T4 CRISPR Activation Plasmid (m2) - sc-420478-ACT-2 from Santa Cruz Biotechnology
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GalNAc-T4 Lentiviral Activation Particles (m) - sc-420478-LAC from Santa Cruz Biotechnology
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GalNAc-T4 Lentiviral Activation Particles (m2) - sc-420478-LAC-2 from Santa Cruz Biotechnology
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GalNAc-T4 siRNA (m) - sc-145312 from Santa Cruz Biotechnology
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GalNAc-T4 shRNA Plasmid (m) - sc-145312-SH from Santa Cruz Biotechnology
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GalNAc-T4 shRNA (m) Lentiviral Particles - sc-145312-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN31707 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND31707 from Sigma-Aldrich
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GALNT4 siRNA (Mouse) - CRM1485 from Cohesion Biosciences
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GALNT4 - MBS8233244 from MyBioSource
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shRNA set against Mouse GALNT4 (NM_015737.4) - SHH299057 from Creative biogene
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Mouse GALNT4 siRNA - orb280961 from Biorbyt
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GALNT4 shRNA Plasmid (Mouse) - CHM1485 from Cohesion Biosciences
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