| Gene Symbol |
TMSB4X
|
| Entrez Gene |
7114
|
| Alt Symbol |
FX, PTMB4, TB4X, TMSB4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
thymosin beta 4, X-linked
|
| Other Description |
prothymosin beta-4|t beta-4|thymosin beta-4|thymosin, beta 4, X chromosome
|
| Swissprots |
Q9UE55 P01254 Q546P5 Q63576 P01253 P62328
|
| Accessions |
CAC43317 EAW98810 EAW98811 EAW98812 EAW98813 EAW98814 P62328 AK055976 AK057827 AK311747 BAG34690 AV715954 BC001631 AAH01631 BC016732 AAH16732 BC022857 AAH22857 BC061586 AAH61586 BC062436 AAH62436 BC064954 AAH64954 BC070248 AAH70248 BC070249 BC083509 AAH83509 BC092437 AAH92437 BC101790 AAI01791 BC101792 AAI01793 BC104464 AAI04465 BC104465 AAI04466 BC104666 AAI04667 BC107789 BC128102 AAI28103 BC128103 AAI28104 BC139925 AAI39926 BC141975 AAI41976 BC141976 AAI41977 BC151215 AAI51216 BT007090 AAP35753 M11948 M17733 AAA36745 X02493 CAA26323 NM_021109 NP_066932
|
| Function |
Plays an important role in the organization of the cytoskeleton (By similarity). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. {ECO:0000250}.
|
| Subcellular Location |
Cytoplasm, cytoskeleton.
|
| Tissue Specificity |
Expressed in several hemopoietic cell lines and lymphoid malignant cells. Decreased levels in myeloma cells. {ECO:0000269|PubMed:3500230}.
|
| Top Pathways |
Regulation of actin cytoskeleton
|
![Western Blot: Thymosin beta 4 Overexpression Lysate (Adult Normal) [NBL1-17128] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Thymosin beta 4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11961_Thymosin%2520beta%25204%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-17128-img0002.jpg)