| Gene Symbol | Hcn2 |
|---|---|
| Entrez Gene | 15166 |
| Alt Symbol | BCNG2, HAC1, trls |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | hyperpolarization-activated, cyclic nucleotide-gated K+ 2 |
| Other Description | BCNG-2|HAC-1|brain cyclic nucleotide-gated channel 2|hyperpolarization-activated cation channel 1|potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2 |
| Swissprots | O88703 O70506 |
| Accessions | AAG43529 EDL31671 O88703 AB154248 BAI44633 AF064873 AAC40125 AJ225122 CAA12406 BC156149 AAI56150 CX242892 NM_008226 NP_032252 |
| Function | Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions. Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). Can also transport ammonium in the distal nephron. Produces a large instantaneous current. {ECO:0000269|PubMed:10962006, ECO:0000269|PubMed:11096117, ECO:0000269|PubMed:11741901, ECO:0000269|PubMed:12034718, ECO:0000269|PubMed:12193608, ECO:0000269|PubMed:12968185, ECO:0000269|PubMed:17562314, ECO:0000269|PubMed:23103389}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:10962006, ECO:0000269|PubMed:11096117, ECO:0000269|PubMed:12034718, ECO:0000269|PubMed:12193608, ECO:0000269|PubMed:17562314, ECO:0000269|PubMed:23103389}; Multi-pass membrane protein {ECO:0000269|PubMed:10962006, ECO:0000269|PubMed:11096117, ECO:0000269|PubMed:12034718, ECO:0000269|PubMed:12193608, ECO:0000269|PubMed:17562314, ECO:0000269|PubMed:23103389}. |
| Tissue Specificity | Highly expressed in brain. Detected at low levels in heart, in ventricle, atrium and in sinoatrial node (SAN). {ECO:0000269|PubMed:9630217}. |
| Top Pathways | cAMP signaling pathway |