| Gene Symbol |
SORBS2
|
| Entrez Gene |
8470
|
| Alt Symbol |
ARGBP2, PRO0618
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sorbin and SH3 domain containing 2
|
| Other Description |
Arg binding protein 2|Arg/Abl-interacting protein 2|sorbin and SH3 domain-containing protein 2
|
| Swissprots |
D3DP63 G3XAI0 O94875 H7BXR4 B3KPQ7 J3KNZ5 B7Z1G5 E9PAW4 A6NEK9 D3DP62 C9JKV9 O60592 O60593 B7Z3X6 Q96EX0 E9PAS5
|
| Accessions |
EAX04630 EAX04631 EAX04632 EAX04633 EAX04634 EAX04635 EAX04636 EAX04637 O94875 AA114994 AB018320 BAA34497 AF049884 AAC05508 AF049885 AAC05509 AF090937 AAF24049 AK056628 BAG51769 AK056758 BAG51806 AK225327 AK225812 AK293400 BAH11501 AK295742 BAH12173 AK296461 BAH12362 AK304653 BAH14233 AK312986 BAG35823 AL134289 AL527982 AM392558 CAL37436 AM392618 CAL37496 AM392656 CAL37534 AM392766 CAL37644 AM392793 CAL37671 AM392850 CAL37728 AM392855 CAL37733 AM392889 CAL37767 AM392933 CAL37811 AM392985 CAL37863 AM393012 CAL37890 AM393014 CAL37892 AM393034 CAL37912 AM393054 CAL37932 AM393056 CAL37934 AM393127 CAL38005 AM393172 CAL38050 AM393190 CAL38068 AM393221 CAL38099 AM393267 CAL38145 AM393367 CAL38245 AM393501 CAL38378 AM393636 CAL38512 AM393650 CAL38526 AM393693 CAL38569 AM393706 CAL38582 AM393834 CAL38709 AU142147 AV658263 BC011883 AAH11883 BC035329 BC069025 BC122526 CB988614 CN340607 DA105517 DA119376 DA139168 DA398113 DA836871 DC421607 EF139852 EU832635 ACE87726 EU832711 ACE87043 XM_005263307 XP_005263364 XM_005263308 XP_005263365 XM_005263310 XP_005263367 XM_005263311 XP_005263368 XM_005263312 XP_005263369 XM_005263313 XP_005263370 XM_006714358 XP_006714421 XM_006714359 XP_006714422 XM_006714365 XP_006714428 XM_006714366 XP_006714429 XM_006714368 XP_006714431 XM_006714369 XP_006714432 XM_006714370 XP_006714433 XM_006714371 XP_006714434 XM_006714372 XP_006714435 XM_006714373 XP_006714436 XM_006714374 XP_006714437 XM_006714375 XP_006714438 XM_006714376 XP_006714439 XM_006714377 XP_006714440 XM_006714378 XP_006714441 XM_006714379 XP_006714442 XM_006714381 XP_006714444 XM_006714383 XP_006714446 XM_006714388 XP_006714451 XM_006714390 XP_006714453 XM_011532362 XP_011530664 XM_011532363 XP_011530665 XM_011532364 XP_011530666 XM_011532365 XP_011530667 XM_011532366 XP_011530668 XM_011532367 XP_011530669 XM_011532368 XP_011530670 XM_011532369 XP_011530671 XM_011532370 XP_011530672 XM_011532371 XP_011530673 XM_011532372 XP_011530674 XM_011532373 XP_011530675 XM_011532374 XP_011530676 XM_011532375 XP_011530677 XM_011532376 XP_011530678 XM_011532377 XP_011530679 XM_011532378 XP_011530680 XM_011532379 XP_011530681 XM_011532380 XP_011530682 XM_011532381 XP_011530683 XM_011532382 XP_011530684 NM_001145670 NP_001139142 NM_001145671 NP_001139143 NM_001145672 NP_001139144 NM_001145673 NP_001139145 NM_001145674 NP_001139146 NM_001145675 NP_001139147 NM_001270771 NP_001257700 NM_003603 NP_003594 NM_021069 NP_066547
|
| Function |
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 or with AKT1 and PAK1, thus mediating AKT1-mediated activation of PAK1. Isoform 6 increases water and sodium absorption in the intestine and gall-bladder. {ECO:0000269|PubMed:12475393, ECO:0000269|PubMed:9211900}.
|
| Subcellular Location |
Cytoplasm, perinuclear region {ECO:0000269|PubMed:16125169, ECO:0000269|PubMed:9211900}. Note=Found at the Z-disk sarcomeres, stress fibers, dense bodies and focal adhesion.
|
| Tissue Specificity |
Abundantly expressed in heart. In cardiac muscle cells, located in the Z-disks of sarcomere. Also found, but to a lower extent, in small and large intestine, pancreas, thymus, colon, spleen, prostate, testis, brain, ovary and epithelial cells. {ECO:0000269|PubMed:11786189, ECO:0000269|PubMed:9211900}.
|