| Gene Symbol | Chst11 |
|---|---|
| Entrez Gene | 58250 |
| Alt Symbol | 1110020P09Rik, C4ST, C4ST-1, C4ST1, C4s |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | carbohydrate sulfotransferase 11 |
| Other Description | C4S-1|chondroitin 4|chondroitin 4-O-sulfotransferase 1|chondroitin 4-sulfotransferase 1 |
| Swissprots | Q9JJS2 Q9JME2 |
| Accessions | EDL21380 Q9JME2 AB030378 BAA92942 AJ289133 CAB92141 AK003880 AK157996 BC137629 AAI37630 BC144793 AAI44794 BQ177147 XM_006513908 XP_006513971 XM_006513909 XP_006513972 NM_021439 NP_067414 |
| Function | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. |
| Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Tissue Specificity | Predominantly expressed in brain and kidney. Also expressed at weaker level in heart, spleen and lung. Expressed in developing chondrocytes. {ECO:0000269|PubMed:10722746}. |
| Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |