Gene Symbol | Chst11 |
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Entrez Gene | 58250 |
Alt Symbol | 1110020P09Rik, C4ST, C4ST-1, C4ST1, C4s |
Species | Mouse |
Gene Type | protein-coding |
Description | carbohydrate sulfotransferase 11 |
Other Description | C4S-1|chondroitin 4|chondroitin 4-O-sulfotransferase 1|chondroitin 4-sulfotransferase 1 |
Swissprots | Q9JJS2 Q9JME2 |
Accessions | EDL21380 Q9JME2 AB030378 BAA92942 AJ289133 CAB92141 AK003880 AK157996 BC137629 AAI37630 BC144793 AAI44794 BQ177147 XM_006513908 XP_006513971 XM_006513909 XP_006513972 NM_021439 NP_067414 |
Function | Catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage and is distributed on the surfaces of many cells and extracellular matrices. Can also sulfate Gal residues in desulfated dermatan sulfate. Preferentially sulfates in GlcA->GalNAc unit than in IdoA->GalNAc unit. Does not form 4, 6- di-O-sulfated GalNAc when chondroitin sulfate C is used as an acceptor. |
Subcellular Location | Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
Tissue Specificity | Predominantly expressed in brain and kidney. Also expressed at weaker level in heart, spleen and lung. Expressed in developing chondrocytes. {ECO:0000269|PubMed:10722746}. |
Top Pathways | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate |
C4ST-1 CRISPR/Cas9 KO Plasmid (m) - sc-425513 from Santa Cruz Biotechnology
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C4ST-1 HDR Plasmid (m) - sc-425513-HDR from Santa Cruz Biotechnology
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C4ST-1 Double Nickase Plasmid (m) - sc-425513-NIC from Santa Cruz Biotechnology
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C4ST-1 Double Nickase Plasmid (m2) - sc-425513-NIC-2 from Santa Cruz Biotechnology
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C4ST-1 CRISPR Activation Plasmid (m) - sc-425513-ACT from Santa Cruz Biotechnology
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C4ST-1 CRISPR Activation Plasmid (m2) - sc-425513-ACT-2 from Santa Cruz Biotechnology
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C4ST-1 Lentiviral Activation Particles (m) - sc-425513-LAC from Santa Cruz Biotechnology
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C4ST-1 Lentiviral Activation Particles (m2) - sc-425513-LAC-2 from Santa Cruz Biotechnology
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C4ST-1 siRNA (m) - sc-60304 from Santa Cruz Biotechnology
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C4ST-1 shRNA Plasmid (m) - sc-60304-SH from Santa Cruz Biotechnology
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C4ST-1 shRNA (m) Lentiviral Particles - sc-60304-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU078371 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN28742 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28742 from Sigma-Aldrich
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CHST11 siRNA (Mouse) - CRM6124 from Cohesion Biosciences
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CHST11 - MBS8201801 from MyBioSource
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shRNA set against Mouse CHST11 (NM_021439.2) - SHH263733 from Creative biogene
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Mouse CHST11 siRNA - orb285600 from Biorbyt
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CHST11 shRNA Plasmid (Mouse) - CHM6124 from Cohesion Biosciences
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CHST11 miRNA 3'UTR clone - MiUTR1M-03030 from Creative biogene
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