| Gene Symbol | Cdk5r1 |
|---|---|
| Entrez Gene | 12569 |
| Alt Symbol | Cdk5r, D11Bwg0379e, p25, p35 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | cyclin-dependent kinase 5, regulatory subunit 1 (p35) |
| Other Description | CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5 regulatory subunit 1|cyclin-dependent kinase 5, regulatory subunit (p35) 1 |
| Swissprots | P61809 |
| Accessions | AAB46777 CAA72176 EDL15645 P61809 AF121847 AAD21195 AK039999 BAE20562 AK043203 BAC31490 AK048617 BAC33394 AK079557 BAC37683 AK084003 AK086621 BAC39703 AK141549 BAE24731 AK142868 AK169667 BAE41289 BC046823 AAH46823 BC050768 AAH50768 BC058697 AAH58697 U89527 AAB49474 NM_009871 NP_034001 |
| Function | p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:17143272, ECO:0000269|PubMed:24235147}. |
| Subcellular Location | Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. |
| Tissue Specificity | Brain and neuron specific. |
| Top Pathways | Alzheimer's disease, Cocaine addiction |