Cdk5r1

Gene Symbol Cdk5r1
Entrez Gene 12569
Alt Symbol Cdk5r, D11Bwg0379e, p25, p35
Species Mouse
Gene Type protein-coding
Description cyclin-dependent kinase 5, regulatory subunit 1 (p35)
Other Description CDK5 activator 1|TPKII regulatory subunit|cyclin-dependent kinase 5 activator 1|cyclin-dependent kinase 5 regulatory subunit 1|cyclin-dependent kinase 5, regulatory subunit (p35) 1
Swissprots P61809
Accessions AAB46777 CAA72176 EDL15645 P61809 AF121847 AAD21195 AK039999 BAE20562 AK043203 BAC31490 AK048617 BAC33394 AK079557 BAC37683 AK084003 AK086621 BAC39703 AK141549 BAE24731 AK142868 AK169667 BAE41289 BC046823 AAH46823 BC050768 AAH50768 BC058697 AAH58697 U89527 AAB49474 NM_009871 NP_034001
Function p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {ECO:0000269|PubMed:17143272, ECO:0000269|PubMed:24235147}.
Subcellular Location Cyclin-dependent kinase 5 activator 1, p35: Cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}.
Tissue Specificity Brain and neuron specific.
Top Pathways Alzheimer's disease, Cocaine addiction

p35 CRISPR/Cas9 KO Plasmid (m) - sc-419603 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

p35 HDR Plasmid (m) - sc-419603-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

p35 Double Nickase Plasmid (m) - sc-419603-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

p35 Double Nickase Plasmid (m2) - sc-419603-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

p35 CRISPR Activation Plasmid (m) - sc-419603-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

p35 CRISPR Activation Plasmid (m2) - sc-419603-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

p35 Lentiviral Activation Particles (m) - sc-419603-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

p35 Lentiviral Activation Particles (m2) - sc-419603-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Mouse

p35 siRNA (m) - sc-36154 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

p35 shRNA Plasmid (m) - sc-36154-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

p35 shRNA (m) Lentiviral Particles - sc-36154-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Mouse

CompoZr® Knockout ZFN Kit - CKOZFN28489 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND28489 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

CDK5R1 siRNA (Mouse) - CRM0642 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

CDK5R1 - MBS8235614 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

shRNA set against Mouse CDK5R1 (NM_009871.2) - SHH260641 from Creative biogene

Category siRNA
Species Reactivities Mouse

shRNA set against Mouse Cdk5r1(NM_009871.2) - SHG164665 from Creative biogene

Category siRNA
Species Reactivities Mouse

Mouse CDK5R1 siRNA - orb280118 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Mouse

CDK5R1 shRNA Plasmid (Mouse) - CHM0642 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Mouse

CDK5R1 miRNA 3'UTR clone - MiUTR1M-02864 from Creative biogene

Species Reactivities Mouse
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