| Gene Symbol |
Tas1r3
|
| Entrez Gene |
83771
|
| Alt Symbol |
Sac, T1r3
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
taste receptor, type 1, member 3
|
| Other Description |
saccharin preference protein|sweet taste receptor T1R3|taste receptor type 1 member 3
|
| Swissprots |
Q925D8 A2ADA0 Q925D9 Q923K0 Q925A4 Q91VA4
|
| Accessions |
AAK01937 AAK55536 AAK55537 BAB62852 EDL15046 Q925D8 AB049994 BAB47181 AF311386 AAL08425 AF337039 AAK39436 AY032621 AAK51602 BC148527 AAI48528 BC153121 AAI53122 NM_031872 NP_114078
|
| Function |
Putative taste receptor. TAS1R1/TAS1R3 responds to the umami taste stimulus (the taste of monosodium glutamate) and also to most of the 20 standard L-amino acids, but not to their D- enantiomers or other compounds. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners. TAS1R3 is essential for the recognition and response to the disaccharide trehalose. Sequence differences within and between species can significantly influence the selectivity and specificity of taste responses. {ECO:0000269|PubMed:11894099, ECO:0000269|PubMed:12892531}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed in circumvallate, foliate and fungiform taste papillae as well as in taste buds on the palate. Also expressed in testis. Not expressed in brain, heart, kidney, liver or spleen. The topographic distribution in various taste papillae is different from those of other T1R members. {ECO:0000269|PubMed:11319557, ECO:0000269|PubMed:11322794, ECO:0000269|PubMed:11326277, ECO:0000269|PubMed:11331418}.
|
| Top Pathways |
Taste transduction, Carbohydrate digestion and absorption
|