| Gene Symbol |
UBE2D1
|
| Entrez Gene |
7321
|
| Alt Symbol |
E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ubiquitin-conjugating enzyme E2D 1
|
| Other Description |
UBC4/5 homolog|stimulator of Fe transport|ubiquitin carrier protein D1|ubiquitin-conjugating enzyme E2 D1|ubiquitin-conjugating enzyme E2(17)KB 1|ubiquitin-conjugating enzyme E2-17 kDa 1|ubiquitin-conjugating enzyme E2D 1 (UBC4/5 homolog, yeast)|ubiquitin-protein ligase D1
|
| Swissprots |
A8K786 P51668 A6NLF6
|
| Accessions |
CAC82097 EAW54167 EAW54168 EAW54169 EAW54170 P51668 AF020761 AF257220 AAM81086 AI566662 AJ272367 CAC82177 AK291901 BAF84590 BC005980 AAH05980 BC015997 AAH15997 BI598342 BM468116 BM970335 BT007041 AAP35690 DA618122 DA677507 DQ893111 ABM84037 DQ896385 ABM87384 X78140 CAA55019 NM_001204880 NP_001191809 NM_003338 NP_003329
|
| Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and auto-ubiquitination of STUB1, TRAF6 and TRIM63/MURF1. Ubiquitinates STUB1-associated HSP90AB1 in vitro. Lacks inherent specificity for any particular lysine residue of ubiquitin. Essential for viral activation of IRF3. Mediates polyubiquitination of CYP3A4. {ECO:0000269|PubMed:18042044, ECO:0000269|PubMed:18359941, ECO:0000269|PubMed:19103148, ECO:0000269|PubMed:19854139, ECO:0000269|PubMed:20061386}.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:18845142}.
|
| Tissue Specificity |
Ubiquitous. Up-regulated in livers of iron- overloaded patients with hereditary hemochromatosis. {ECO:0000269|PubMed:12480712, ECO:0000269|PubMed:9362508}.
|
| Top Pathways |
Ubiquitin mediated proteolysis, Protein processing in endoplasmic reticulum
|
