| Gene Symbol |
CDC14
|
| Entrez Gene |
850585
|
| Alt Symbol |
OAF3
|
| Species |
Yeast
|
| Gene Type |
protein-coding
|
| Description |
phosphoprotein phosphatase CDC14
|
| Other Description |
-
|
| Swissprots |
D6VTQ8 Q05673 Q00684 Q05180
|
| Accessions |
DAA12468 Q00684 NM_001179993 NP_116684
|
| Function |
Protein phosphatase which antagonizes mitotic cyclin- dependent kinase CDC28, the inactivation of which is essential for exit from mitosis. To access its substrates, is released from nucleolar sequestration during mitosis. Plays an essential in coordinating the nuclear division cycle with cytokinesis through the cytokinesis checkpoint. Involved in chromosome segregation, where it is required for meiosis I spindle dissambly as well as for establishing two consecutive chromosome segregation phases. Allows damaged actomyosin rings to be maintained to facilitate completion of cell division in response to minor perturbation of the cell division machinery. Inhibits transcription of ribosomal genes (rDNA) during anaphase and controls segregation of nucleolus by facilitating condensin targeting to rDNA chromatin in anaphase. Dephosphorylates SIC1, a CDC28 inhibitor, and SWI5, a transcription factor for SIC1, and induces degradation of mitotic cyclins, likely by dephosphorylating the activator
|
| Subcellular Location |
Nucleus, nucleolus. Cytoplasm. Bud neck. Note=Sequestered in the nucleolus for most of the cell cycle by the nucleolar proteins NET1 and TOF2, and is released into the nucleus and cytoplasm during anaphase. CDC55 maintains CDC14 sequestration in the nucleolus during early meiosis, which is essential for the assembly of the meiosis I spindle. In anaphase, the CDC14 early anaphase release (FEAR) network (including CDC5, ESP1, and SLK19), and the mitotic exit network (including the DBF2-MOB1 complex) coordinately trigger the release of CDC14 from the nucleolus.
|
| Top Pathways |
Cell cycle - yeast, Meiosis - yeast
|
