| Gene Symbol |
EHMT2
|
| Entrez Gene |
10919
|
| Alt Symbol |
BAT8, C6orf30, G9A, GAT8, KMT1C, NG36
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
euchromatic histone-lysine N-methyltransferase 2
|
| Other Description |
G9A histone methyltransferase|H3-K9-HMTase 3|HLA-B associated transcript 8|ankyrin repeat-containing protein|histone H3-K9 methyltransferase 3|histone-lysine N-methyltransferase EHMT2|histone-lysine N-methyltransferase, H3 lysine-9 specific 3|lysine N-methyltransferase 1C
|
| Swissprots |
Q9Y331 Q9UQL8 Q6PK06 Q5JQA1 Q5JP83 B0UZY2 Q5JQG3 Q5JQ92 Q96QD0 Q96KQ7 Q14349 Q96MH5
|
| Accessions |
AAD21811 AAD21812 BAB63294 BAB63295 EAX03540 EAX03541 EAX03542 EAX03543 EAX03544 Q96KQ7 AB209433 BAD92670 AJ315532 CAC86666 AK056936 BAB71314 AK092866 AK302904 BAH13838 BC002686 AAH02686 BC009351 AAH09351 BC018718 AAH18718 BC020970 AAH20970 CN397400 DA099526 DA106400 HY067184 X69838 CAA49491 XM_005248824 XP_005248881 XM_005272767 XP_005272824 XM_005274833 XP_005274890 XM_005274835 XP_005274892 XM_005274913 XP_005274970 XM_005275207 XP_005275264 XM_005275209 XP_005275266 XM_005275343 XP_005275400 XM_005275345 XP_005275402 XM_006714974 XP_006715037 XM_006714975 XP_006715038 XM_006714976 XP_006715039 XM_006725028 XP_006725091 XM_006725029 XP_006725092 XM_006725467 XP_006725530 XM_006725468 XP_006725531 XM_006725469 XP_006725532 XM_006725682 XP_006725745 XM_006725683 XP_006725746 XM_006725684 XP_006725747 XM_006725892 XP_006725955 XM_006725893 XP_006725956 XM_006725981 XP_006726044 XM_006725982 XP_006726045 NM_001289413 NP_001276342 NM_006709 NP_006700 NM_025256 NP_079532
|
| Function |
Histone methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. Also mediates monomethylation of 'Lys-56' of histone H3 (H3K56me1) in G1 phase, leading to promote interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates 'Lys-27' of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Probably targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of 'Lys- 373' of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 an
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11316813}. Chromosome {ECO:0000269|PubMed:11316813}. Note=Associates with euchromatic regions. Does not associate with heterochromatin.
|
| Tissue Specificity |
Expressed in all tissues examined, with high levels in fetal liver, thymus, lymph node, spleen and peripheral blood leukocytes and lower level in bone marrow. {ECO:0000269|PubMed:11707778}.
|
| Top Pathways |
Lysine degradation
|