EPM2A

Gene Symbol	EPM2A
Entrez Gene	7957
Alt Symbol	EPM2, MELF
Species	Human
Gene Type	protein-coding
Description	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
Other Description	LAFPTPase|epilepsy, progressive myoclonus type 2, Lafora disease (laforin)|glucan phosphatase|lafora PTPase|laforin
Swissprots	Q9BS66 Q6IS15 B3KMU5 O95278 Q9UEN2 Q5T3F5 Q8IX25 O95483 B4DRZ2 Q8IU96 Q8IX24
Accessions	B3EWF7 EAW47842 EAW47843 EAW47844 O95278 AF084535 AAC83347 AF284580 AAG18377 AF454491 AAO15523 AF454492 AAO15524 AF454493 AAO15525 AF454494 AAO15526 AJ130763 CAA10199 AJ130764 CAA10200 AK022721 BAG51107 AK299497 BAG61454 AW291546 BC005286 AAH05286 BC070047 AAH70047 BI463677 HG499755 XM_006715564 XP_006715627 XM_011536113 XP_011534415 XM_011536114 XP_011534416 XM_011536115 XP_011534417 XM_011536116 XP_011534418 NM_001018041 NP_001018051 NM_005670 NP_005661
Function	Has both dual-specificity protein phosphatase and glucan phosphatase activities. Together with the E3 ubiquitin ligase NHLRC1/malin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. Dephosphorylates phosphotyrosine, phosphoserine and phosphothreonine substrates in vitro. Has also been shown to dephosphorylate MAPT. Shows strong phosphatase activity towards complex carbohydrates in vitro, avoiding glycogen hyperphosphorylation which is associated with reduced branching and formation of insoluble aggregates. Forms a complex with NHLRC1/malin and HSP70, which suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Acts as a scaffold protein to facilitate PPP1R3C/PTG ubiquitination by NHLRC1/malin. Also promotes proteasome-independent protein degradation through the macroautophagy pathway. Isoform 2, an inactive phosphatase, could function as a dominant-ne
Subcellular Location	Isoform 5: Cytoplasm. Nucleus.
Tissue Specificity	Expressed in heart, skeletal muscle, kidney, pancreas and brain. Isoform 4 is also expressed in the placenta. {ECO:0000269|PubMed:9771710}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EPM2A peptide (320-331) - ab45659 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human EPM2A full length protein - ab132422 from Abcam Category Protein Source Wheat germ Species Human

Human EPM2A protein fragment - ab159917 from Abcam Category Protein Source Wheat germ Species Human

EPM2A-Antibody-C-term-Blocking-Peptide - BP1453b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Laforin (isoform a) blocking peptide - GTX88479-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Bovine

EPM2A Peptide - AC21-1570-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Laforin - H00007957-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

Laforin - H00007957-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Laforin - H00007957-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Laforin - H00007957-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Laforin (C-term) Control Peptide - AP55481CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

EPM2A Peptide - 7023P from ProSci Category Peptide Species Human

EPM2A Peptide - 46-781P from ProSci Category Peptide Species Human

Recombinant Human Laforin, isoform 9(EPM2A) - CSB-YP464991HU CSB-EP464991HU CSB-BP464991HU CSB-MP464991HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human Laforin(EPM2A) - CSB-YP007738HU CSB-EP007738HU CSB-BP007738HU CSB-MP007738HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Epilepsy, Progressive Myoclonus Type 2A, Peptide - MBS659638 from MyBioSource Category Peptide Prices $340.00 Sizes 100 µg

Laforin, Peptide - MBS425621 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Bovine

Laforin/EPM2A Recombinant Protein Antigen - NBP2-49185PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

Laforin/EPM2A Recombinant Protein Antigen - NBP2-49093PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

EPM2A-Antibody-N-term-Blocking-Peptide - BP1453a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Laforin, isoform 9(EPM2A), Mammalian cell - CSB-MP464991HU from Cusabio Category Protein Source Mammalian cell Species Human

Recombinant Human Laforin, isoform 9(EPM2A), Baculovirus - CSB-BP464991HU from Cusabio Category Protein Source Baculovirus Species Human

Recombinant Human Laforin, isoform 9(EPM2A), Escherichia Coli - CSB-EP464991HU from Cusabio Category Protein Source E.coli Species Human

Laforin (EPM2A), Recombinant Protein - MBS1085145 from MyBioSource Category Protein Prices $1,090.00, $1,090.00, $1,320.00, $1,320.00, $1,720.00, $1,720.00, $2,185.00, $2,185.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Laforin, isoform 9 (EPM2A), Recombinant Protein - MBS1142264 from MyBioSource Category Protein Prices $1,105.00, $1,105.00, $1,340.00, $1,340.00, $1,750.00, $1,750.00, $2,215.00, $2,215.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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