MAPK1

Gene Symbol	MAPK1
Entrez Gene	5594
Alt Symbol	ERK, ERK-2, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk, p42-MAPK
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase 1
Other Description	MAP kinase 1|MAP kinase 2|MAP kinase isoform p42|MAPK 2|extracellular signal-regulated kinase 2|mitogen-activated protein kinase 2|protein tyrosine kinase ERK2
Swissprots	P28482 A8CZ64
Accessions	ABF47102 ABY87541 AGC09596 CBK51146 EAW59479 EAW59480 EAW59481 EAW59482 P28482 AI004470 AK055080 AK057143 AK090869 AK295188 BAG58192 AK307615 BC017832 AAH17832 BC099905 AAH99905 BQ774391 DQ399292 ABD60303 EF565108 EU176323 ABW03774 EU831429 ACE87116 EU831522 ACE86441 Z11694 CAA77752 Z11695 CAA77753 NM_002745 NP_002736 NM_138957 NP_620407
Function	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organel
Subcellular Location	Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm. Note=Associated with the spindle during prometaphase and metaphase (By similarity). PEA15- binding and phosphorylated DAPK1 promote its cytoplasmic retention. Phosphorylation at Ser- 246 and Ser-248 as well as autophosphorylation at Thr-190 promote nuclear localization. {ECO:0000250}.
Top Pathways	TGF-beta signaling pathway, Adherens junction, Axon guidance, VEGF signaling pathway, Focal adhesion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active ERK2 full length protein - ab155812 from Abcam Category Protein Prices $239.00, $302.00 Sizes 5 µg, 10 µg Source E. coli

ERK1 + ERK2 peptide - ab108469 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ERK2 peptide - ab7992 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

ERK2 peptide (9-19) - ab45662 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human ERK2 full length protein - ab43625 from Abcam Category Protein Source E. coli Species Human

Human ERK2 full length protein - ab43624 from Abcam Category Protein Source E. coli Species Human

Human ERK2 full length protein - ab95379 from Abcam Category Protein Source E. coli Species Human

Human ERK2 full length protein - ab82194 from Abcam Category Protein Source E. coli Species Human

Mouse ERK2 full length protein - ab62568 from Abcam Category Protein Source E. coli Species Mouse

MAPK1 / ERK2 Antibody Blocking Peptide - LS-E25807 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK1 / ERK2 Antibody Blocking Peptide - LS-E22355 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK1 / ERK2 Antibody Blocking Peptide - LS-E21554 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK1 / ERK2 Antibody Blocking Peptide - LS-E21553 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MAPK1 / ERK2 Antibody Blocking Peptide - LS-E9009 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ERK2 Protein - NBP1-30309 from Novus Biologicals Category Protein Prices $279.00 Sizes 100 µg Species Human

ERK2 Recombinant Protein - H00005594-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ERK2 Partial Recombinant Protein - H00005594-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

ERK2 Recombinant Protein - P4689 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

ERK2 Peptide - P2501 from Novus Biologicals Category Peptide Species Human

ERK2 Peptide - P2429 from Novus Biologicals Category Peptide Species Human

MAPK1-Antibody-T204-Blocking-Peptide - BP7250e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAPK1-Antibody-T184-Blocking-Peptide - BP7250d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAPK1-Antibody-C-term-Blocking-Peptide - BP7250b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MAPK1-Antibody-C-term-Blocking-peptide - BP7501a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Active ERK2, CF - 1230-KS-010 from R&D Systems Category Protein

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