SLC1A1

Gene Symbol	SLC1A1
Entrez Gene	6505
Alt Symbol	DCBXA, EAAC1, EAAT3, SCZD18
Species	Human
Gene Type	protein-coding
Description	solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
Other Description	excitatory amino acid carrier 1|excitatory amino acid transporter 3|neuronal and epithelial glutamate transporter|sodium-dependent glutamate/aspartate transporter 3|solute carrier family 1 member 1
Swissprots	Q9UEW2 Q8N199 O75587 Q5VZ24 P43005
Accessions	AAC27511 EAW58786 P43005 AB008536 BAB83767 AF037982 AAC25029 AK313013 BAG35848 BC033040 AAH33040 BQ008494 BQ029108 CB984615 CK903716 DA643262 DQ892425 ABM83351 DQ895639 ABM86565 U03506 AAA50430 U06469 AAA53215 U08989 AAA68628 XM_011518007 XP_011516309 XM_011518008 XP_011516310 XM_011518009 XP_011516311 XM_011518010 XP_011516312 NM_004170 NP_004161
Function	Transports L-glutamate, L- and D-aspartate and L-cystein (PubMed:21123949). Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. Negatively regulated by ARL6IP5 (By similarity). {ECO:0000250|UniProtKB:P51906, ECO:0000250|UniProtKB:P51907, ECO:0000269|PubMed:21123949}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein. Apical cell membrane {ECO:0000269|PubMed:21123949}; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
Tissue Specificity	Expressed in all tissues tested including liver, muscle, testis, ovary, retinoblastoma cell line, neurons and brain (in which there was dense expression in substantia nigra, red nucleus, hippocampus and in cerebral cortical layers). {ECO:0000269|PubMed:7521911, ECO:0000269|PubMed:7859077, ECO:0000269|PubMed:7914198}.
Top Pathways	Protein digestion and absorption, Glutamatergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

EAAT3 (E1E6M) Rabbit mAb - 14501 from Cell Signaling Technology Prices $246.00 Sizes 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone E1E6M

EAAT3 Antibody - 12179 from Cell Signaling Technology Host Rabbit Clonality Polyclonal

EAAT3 (H-70) - sc-25658 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

EAAT3 (C-20) - sc-7761 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-EAAT3 antibody - ab135858 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-EAAT3 antibody - ab99101 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-EAAT3 antibody [EPR6774(B)] - ab124802 from Abcam Prices $385.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR6774(B)

Anti-EAAT3 antibody [S180-41] - ab131429 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S180-41

Anti-EAAT3 antibody - Extracellular domain - ab81109 from Abcam Prices $376.00 Sizes 500 µg Host Rabbit Clonality Polyclonal

Anti-EAAT3 antibody - N-terminal - ab191288 from Abcam Prices $376.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC1A1 / EAAT3 Antibody (aa10-27) - LS-C343924 from LifeSpan Bioscience Prices $305.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC1A1 / EAAT3 Antibody (Internal, clone EPR6774(B)) IHC-plus™ - LS-B9480 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Monoclonal Clone EPR6774(B)

Anti-SLC1A1 / EAAT3 Antibody (C-Terminus) - LS-C15439 from LifeSpan Bioscience Prices $365.00 Sizes 50 µl Host Rabbit Clonality Polyclonal

Anti-SLC1A1 / EAAT3 Antibody (C-Terminus) - LS-C15444 from LifeSpan Bioscience Prices $515.00 Sizes 50 µl Host Goat Clonality Polyclonal

Anti-SLC1A1 / EAAT3 Antibody (C-Terminus) - LS-C15445 from LifeSpan Bioscience Prices $465.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SLC1A1 / EAAT3 Antibody (aa150-200) - LS-C94138 from LifeSpan Bioscience Prices $325.00 Sizes 500 µg Host Rabbit Clonality Polyclonal

Anti-SLC1A1 / EAAT3 Antibody (aa36-85) - LS-C110832 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SLC1A1 / EAAT3 Antibody (aa143-192) - LS-C110833 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SLC1A1 / EAAT3 Antibody (C-Terminus) - LS-C136976 from LifeSpan Bioscience Prices $255.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-SLC1A1 / EAAT3 Antibody (aa510-523) - LS-C152890 from LifeSpan Bioscience Prices $365.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-SLC1A1 / EAAT3 Antibody (aa1-524, clone S180-41, Atto 390) - LS-C231706 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S180-41

Anti-SLC1A1 / EAAT3 Antibody (aa1-524, clone S180-41, Atto 488) - LS-C231709 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S180-41

Anti-SLC1A1 / EAAT3 Antibody (aa1-524, clone S180-41, Atto 565) - LS-C231710 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S180-41

Anti-SLC1A1 / EAAT3 Antibody (Pro171) - LS-C177246 from LifeSpan Bioscience Prices $345.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-SLC1A1 / EAAT3 Antibody (aa1-524, clone S180-41, Atto 594) - LS-C231711 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone S180-41

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