| Gene Symbol |
Lrrk2
|
| Entrez Gene |
66725
|
| Alt Symbol |
4921513O20Rik, 9330188B09Rik, AW561911, D630001M17Rik, Gm927, cI-46
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
leucine-rich repeat kinase 2
|
| Other Description |
leucine-rich repeat serine/threonine-protein kinase 2
|
| Swissprots |
Q8K062 E9QNJ2 Q8CI84 Q8BZJ6 Q5S006 Q8BWG7
|
| Accessions |
Q5S006 AK014886 BAB29603 AK014938 BAB29628 AK034413 BAC28700 AK050702 AK052591 BAC35052 AK086917 BAC39762 AK156100 AY792512 AAV63976 BC034074 AAH34074 BC035949 AAH35949 BF660966 XM_006521276 XP_006521339 XM_006521277 XP_006521340 XR_875310 NM_025730 NP_080006
|
| Function |
Positively regulates autophagy through a calcium- dependent activation of the CaMKK/AMPK signaling pathway. The process involves activation of nicotinic acid adenine dinucleotide phosphate (NAADP) receptors, increase in lysosomal pH, and calcium release from lysosomes. Together with RAB29, plays a role in the retrograde trafficking pathway for recycling proteins, such as mannose 6 phosphate receptor (M6PR), between lysosomes and the Golgi apparatus in a retromer-dependent manner. Regulates neuronal process morphology in the intact central nervous system (CNS). Phosphorylates PRDX3. Has GTPase activity (By similarity). {ECO:0000250|UniProtKB:Q5S007}.
|
| Subcellular Location |
Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasm {ECO:0000250}. Perikaryon {ECO:0000250}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Golgi apparatus {ECO:0000269|PubMed:17120249}. Endoplasmic reticulum {ECO:0000269|PubMed:17120249}. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000250|UniProtKB:Q5S007, ECO:0000269|PubMed:17120249}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q5S007}; Cytoplasmic side {ECO:0000250|UniProtKB:Q5S007}. Endosome {ECO:0000269|PubMed:17120249}. Lysosome {ECO:0000269|PubMed:17120249}. Mitochondrion outer membrane {ECO:0000269|PubMed:17120249}. Mitochondrion inner membrane {ECO:0000269|PubMed:17120249}. Mitochondrion matrix {ECO:0000269|PubMed:17120249}. Note=Localized in the cytoplasm and associated with cellular membrane structures. Colocalized with RAB29 along tubular structures emerging from Golgi apparatus. Localizes in intracytoplasmic punctate structures of ne
|
| Tissue Specificity |
Expressed in the brain (at protein level). Detected throughout the adult brain. Expressed in deep cerebral cortex layers, superficial cingulate cortex layers, the piriform cortex, hippocampal formation, caudate putamen, substantia nigra, the basolateral and basomedial anterior amygdala nuclei, reticular thalamic nucleus and also in the cerebellar granular cell layer. Highly expressed in the striatum, cortex and olfactory tubercle. Little or no expression in the substantia nigra, where dopaminergic neurons preferentially degenerate in Parkinson disease. Expression is particularly high in brain dopaminoceptive areas. High and strikingly specific expression in striatum and parts of cortex and no signals in dopamine neurons. {ECO:0000269|PubMed:16487147, ECO:0000269|PubMed:16504409, ECO:0000269|PubMed:16532471, ECO:0000269|PubMed:17120249}.
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