| Gene Symbol | PPP2R5A |
|---|---|
| Entrez Gene | 5525 |
| Alt Symbol | B56A, PR61A |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 2, regulatory subunit B', alpha |
| Other Description | PP2A B subunit isoform B'-alpha|PP2A B subunit isoform B56-alpha|PP2A B subunit isoform PR61-alpha|PP2A B subunit isoform R5-alpha|PP2A, B subunit, B' alpha isoform|PP2A, B subunit, B56 alpha isoform|PP2A, B subunit, PR61 alpha isoform|PP2A, B subunit, R5 alpha isoform|PR61alpha|protein phosphatase 2, regulatory subunit B (B56), alpha isoform|protein phosphatase 2, regulatory subunit B', alpha isoform|serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform|serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform |
| Swissprots | B7Z7L2 B2R6D2 Q8TBI9 D3DT99 Q15172 Q5VVB2 Q2NL72 |
| Accessions | EAW93392 EAW93393 Q15172 AA425592 AK302202 BAH13648 AK312530 BAG35429 BC022474 AAH22474 BC110883 AAI10884 BM974076 BP326450 DQ892361 ABM83287 DQ895568 ABM86494 L42373 AAC37601 NM_001199756 NP_001186685 NM_006243 NP_006234 |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:8703017}. Nucleus {ECO:0000269|PubMed:8703017}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase. {ECO:0000269|PubMed:16541025}. |
| Tissue Specificity | Widely expressed with the highest expression in heart and skeletal muscle. |
| Top Pathways | Oocyte meiosis, mRNA surveillance pathway, Dopaminergic synapse, PI3K-Akt signaling pathway, Adrenergic signaling in cardiomyocytes |