PPP2R5A
| Gene Symbol | PPP2R5A |
|---|---|
| Entrez Gene | 5525 |
| Alt Symbol | B56A, PR61A |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein phosphatase 2, regulatory subunit B', alpha |
| Other Description | PP2A B subunit isoform B'-alpha|PP2A B subunit isoform B56-alpha|PP2A B subunit isoform PR61-alpha|PP2A B subunit isoform R5-alpha|PP2A, B subunit, B' alpha isoform|PP2A, B subunit, B56 alpha isoform|PP2A, B subunit, PR61 alpha isoform|PP2A, B subunit, R5 alpha isoform|PR61alpha|protein phosphatase 2, regulatory subunit B (B56), alpha isoform|protein phosphatase 2, regulatory subunit B', alpha isoform|serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, alpha isoform|serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform |
| Swissprots | B7Z7L2 B2R6D2 Q8TBI9 D3DT99 Q15172 Q5VVB2 Q2NL72 |
| Accessions | EAW93392 EAW93393 Q15172 AA425592 AK302202 BAH13648 AK312530 BAG35429 BC022474 AAH22474 BC110883 AAI10884 BM974076 BP326450 DQ892361 ABM83287 DQ895568 ABM86494 L42373 AAC37601 NM_001199756 NP_001186685 NM_006243 NP_006234 |
| Function | The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:8703017}. Nucleus {ECO:0000269|PubMed:8703017}. Chromosome, centromere {ECO:0000269|PubMed:16541025}. Note=From mitotic prophase to metaphase, localizes at the inner centromere between a pair of sister kinetochores. Decreased expression at the onset of anaphase. {ECO:0000269|PubMed:16541025}. |
| Tissue Specificity | Widely expressed with the highest expression in heart and skeletal muscle. |
| Top Pathways | Oocyte meiosis, mRNA surveillance pathway, Dopaminergic synapse, PI3K-Akt signaling pathway, Adrenergic signaling in cardiomyocytes |
PP2A-B56-α CRISPR/Cas9 KO Plasmid (h) - sc-402457 from Santa Cruz Biotechnology
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PP2A-B56-α HDR Plasmid (h) - sc-402457-HDR from Santa Cruz Biotechnology
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PP2A-B56-α Double Nickase Plasmid (h) - sc-402457-NIC from Santa Cruz Biotechnology
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PP2A-B56-α Double Nickase Plasmid (h2) - sc-402457-NIC-2 from Santa Cruz Biotechnology
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PP2A-B56-α CRISPR Activation Plasmid (h) - sc-402457-ACT from Santa Cruz Biotechnology
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PP2A-B56-α CRISPR Activation Plasmid (h2) - sc-402457-ACT-2 from Santa Cruz Biotechnology
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PP2A-B56-α Lentiviral Activation Particles (h) - sc-402457-LAC from Santa Cruz Biotechnology
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PP2A-B56-α Lentiviral Activation Particles (h2) - sc-402457-LAC-2 from Santa Cruz Biotechnology
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PP2A-B56-α siRNA (h) - sc-39181 from Santa Cruz Biotechnology
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PP2A-B56-α shRNA Plasmid (h) - sc-39181-SH from Santa Cruz Biotechnology
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PP2A-B56-α shRNA (h) Lentiviral Particles - sc-39181-V from Santa Cruz Biotechnology
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PPP2R5A RNAi - H00005525-R01 from Novus Biologicals
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MISSION® esiRNA - EHU022651 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0635 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0634 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0636 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17299 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17299 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07847 from Sigma-Aldrich
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PPP2R5A siRNA (Human) - CRH3704 from Cohesion Biosciences
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shRNA set against Human PPP2R5A (NM_006243.3) - SHH381472 from Creative biogene
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PPP2R5A shRNA Plasmid (Human) - CHH3704 from Cohesion Biosciences
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PPP2R5A miRNA 3'UTR clone - MiUTR3H-04280 from Creative biogene
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