| Gene Symbol |
VSIG4
|
| Entrez Gene |
11326
|
| Alt Symbol |
CRIg, Z39IG
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
V-set and immunoglobulin domain containing 4
|
| Other Description |
Ig superfamily protein|V-set and immunoglobulin domain-containing protein 4|complement receptor of the immunoglobulin superfamily|protein Z39Ig
|
| Swissprots |
Q9Y279 Q6UXI4
|
| Accessions |
CAG24387 CAV28320 CAV28321 CBI69253 CBI69254 EAX05393 EAX05394 EAX05395 Q9Y279 AJ132502 CAB51536 AK075153 BAG52076 AK075171 AK293215 BAG56754 AK297050 BAG59576 AK298389 BAG60624 AK301417 BAG62947 AL542949 AL552873 AL553835 AY358341 AAQ88707 BC010525 AAH10525 BP292528 BX482258 CA310184 CA405669 DQ891770 ABM82696 DQ894953 ABM85879 NM_001100431 NP_001093901 NM_001184830 NP_001171759 NM_001184831 NP_001171760 NM_001257403 NP_001244332 NM_007268 NP_009199
|
| Function |
Phagocytic receptor, strong negative regulator of T-cell proliferation and IL2 production. Potent inhibitor of the alternative complement pathway convertases. {ECO:0000269|PubMed:17016562, ECO:0000269|PubMed:17051150}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Abundantly expressed in several fetal tissues. In adult tissues, highest expression in lung and placenta. Expressed in resting macrophages. {ECO:0000269|PubMed:11004523, ECO:0000269|PubMed:17016562}.
|