| Gene Symbol |
Clspn
|
| Entrez Gene |
269582
|
| Alt Symbol |
B130025E01, C85083, E130314M08Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
claspin
|
| Other Description |
claspin homolog
|
| Swissprots |
Q69GM2 B1ARX6 Q80YR7
|
| Accessions |
EDL30282 EDL30283 Q80YR7 AK045076 BAC32211 AK051966 BAC34822 AK053847 AK135394 AK136174 AK161785 BAE36572 AY324187 AAP97538 BC050848 AAH50848 CF535627 XM_006503122 XP_006503185 XM_006503123 XP_006503186 XM_006503124 XP_006503187 XM_006503125 XP_006503188 XM_011240540 XP_011238842 XM_011240541 XP_011238843 NM_175554 NP_780763
|
| Function |
Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation. Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR- dependent phosphorylation of both proteins. Can also bind specifically to branched DNA structures and may associate with S- phase chromatin following formation of the pre-replication complex (pre-RC). This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Chromosome {ECO:0000250}.
|