| Gene Symbol |
mfsd2aa
|
| Entrez Gene |
492810
|
| Alt Symbol |
NLS1-A, mfsd2a, zgc:101615
|
| Species |
Zebrafish
|
| Gene Type |
protein-coding
|
| Description |
major facilitator superfamily domain containing 2aa
|
| Other Description |
major facilitator superfamily domain containing 2a|major facilitator superfamily domain-containing protein 2A-A|sodium-dependent LPC symporter 1-A|sodium-dependent lysophosphatidylcholine symporter 1-A
|
| Swissprots |
Q5U3U7
|
| Accessions |
Q5U3U7 BC085388 AAH85388 XM_005156993 XP_005157050 XM_009307472 XP_009305747 NM_001007451 NP_001007452
|
| Function |
Sodium-dependent lysophosphatidylcholine (LPC) symporter, which plays an essential role for blood-brain barrier formation and function. Specifically expressed in endothelium of the blood-brain barrier of micro-vessels and transports LPC into the brain. Transport of LPC is essential because it constitutes the major mechanism by which docosahexaenoic acid (DHA), an omega- 3 fatty acid that is essential for normal brain growth and cognitive function, enters the brain. Transports LPC carrying long-chain fatty acids such LPC oleate and LPC palmitate with a minimum acyl chain length of 14 carbons. Does not transport docosahexaenoic acid in unesterified fatty acid. Specifically required for blood-brain barrier formation and function, probably by mediating lipid transport (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|