Bcl2

Gene Symbol Bcl2
Entrez Gene 24224
Alt Symbol Bcl-2
Species Rat
Gene Type protein-coding
Description B-cell CLL/lymphoma 2
Other Description B cell lymphoma 2 associated oncogene|B-cell leukemia/lymphoma 2|Bcl2-like protein|apoptosis regulator Bcl-2
Swissprots Q62837 P49950 Q64032
Accessions P49950 AF149299 AAD48410 AF512835 AAP47159 L14680 AAA53662 U34964 AAA77687 NM_016993 NP_058689
Function Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
Subcellular Location Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
Tissue Specificity Expressed in a variety of tissues, with highest levels in reproductive tissues. In the adult brain, expression is localized in mitral cells of the olfactory bulb, granule and pyramidal neurons of hippocampus, pontine nuclei, cerebellar granule neurons, and in ependymal cells. In prenatal brain, expression is higher and localized in the neuroepithelium and in the cortical plate.
Top Pathways Toxoplasmosis, Epstein-Barr virus infection, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway

Rat BCL2 gene - orb93094 from Biorbyt

Prices $264.00
Sizes 10 μg
Species Rat

Rat Bcl2 ORF Clone(NM_016993.1) - CDCR378106 from Creative biogene

Species Rat

Rat Bcl2 cDNA Clone(NM_016993.1) - CDFR011008 from Creative biogene

Species Rat
Search more