| Gene Symbol |
Bcl2
|
| Entrez Gene |
24224
|
| Alt Symbol |
Bcl-2
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
B-cell CLL/lymphoma 2
|
| Other Description |
B cell lymphoma 2 associated oncogene|B-cell leukemia/lymphoma 2|Bcl2-like protein|apoptosis regulator Bcl-2
|
| Swissprots |
Q62837 P49950 Q64032
|
| Accessions |
P49950 AF149299 AAD48410 AF512835 AAP47159 L14680 AAA53662 U34964 AAA77687 NM_016993 NP_058689
|
| Function |
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1).
|
| Subcellular Location |
Mitochondrion outer membrane; Single-pass membrane protein. Nucleus membrane; Single-pass membrane protein. Endoplasmic reticulum membrane; Single-pass membrane protein.
|
| Tissue Specificity |
Expressed in a variety of tissues, with highest levels in reproductive tissues. In the adult brain, expression is localized in mitral cells of the olfactory bulb, granule and pyramidal neurons of hippocampus, pontine nuclei, cerebellar granule neurons, and in ependymal cells. In prenatal brain, expression is higher and localized in the neuroepithelium and in the cortical plate.
|
| Top Pathways |
Toxoplasmosis, Epstein-Barr virus infection, MicroRNAs in cancer, Adrenergic signaling in cardiomyocytes, Sphingolipid signaling pathway
|