| Gene Symbol | ARNTL |
|---|---|
| Entrez Gene | 406 |
| Alt Symbol | BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5 |
| Species | Human |
| Gene Type | protein-coding |
| Description | aryl hydrocarbon receptor nuclear translocator-like |
| Other Description | ARNT-like protein 1, brain and muscle|PAS domain-containing protein 3|aryl hydrocarbon receptor nuclear translocator-like protein 1|bHLH-PAS protein JAP3|basic-helix-loop-helix-PAS orphan MOP3|basic-helix-loop-helix-PAS protein MOP3|brain and muscle ARNT-like 1|class E basic helix-loop-helix protein 5|member of PAS protein 3|member of PAS superfamily 3 |
| Swissprots | Q99631 O00316 B5ME11 B7WPG7 A2I2N6 O00327 Q8IUT4 D3DQW6 Q4G136 O00315 O00314 O00313 O00317 Q99649 A8K645 |
| Accessions | ABM64205 BAA19936 EAW68503 EAW68504 EAW68505 EAW68506 EAW68507 EAW68508 EAW68509 EAW68510 EAW68511 EAW68512 EAW68513 O00327 AB000812 BAA19935 AB000814 BAA19937 AB000815 BAA19938 AB000816 BAA19939 AF044288 AAC24353 AK095749 BAG53120 AK128317 AK291510 BAF84199 AK315174 BAG37615 BC016674 AAH16674 BC031214 AAH31214 BC041129 AAH41129 BE391243 D89722 BAA19968 EU446463 ABZ91992 JF432385 ADZ15602 U51627 AAC51213 U60415 AAB37248 XM_006718233 XP_006718296 XM_006718234 XP_006718297 XM_011520105 XP_011518407 XM_011520106 XP_011518408 XM_011520107 XP_011518409 XM_011520108 XP_011518410 XM_011520109 XP_011518411 XM_011520110 XP_011518412 XM_011520111 XP_011518413 XM_011520112 XP_011518414 XM_011520113 XP_011518415 NM_001030272 NP_001025443 NM_001030273 NP_001025444 NM_001178 NP_001169 NM_001297719 NP_001284648 NM_001297722 NP_001284651 NM_001297724 NP_001284653 |
| Function | Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:24005054}. Cytoplasm {ECO:0000250|UniProtKB:Q9WTL8}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9WTL8}. Note=Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. {ECO:0000250|UniProtKB:Q9WTL8}. |
| Tissue Specificity | Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart. {ECO:0000269|PubMed:24005054}. |
| Top Pathways | Circadian rhythm, Herpes simplex infection, Dopaminergic synapse |