ARNTL

Gene Symbol	ARNTL
Entrez Gene	406
Alt Symbol	BMAL1, BMAL1c, JAP3, MOP3, PASD3, TIC, bHLHe5
Species	Human
Gene Type	protein-coding
Description	aryl hydrocarbon receptor nuclear translocator-like
Other Description	ARNT-like protein 1, brain and muscle|PAS domain-containing protein 3|aryl hydrocarbon receptor nuclear translocator-like protein 1|bHLH-PAS protein JAP3|basic-helix-loop-helix-PAS orphan MOP3|basic-helix-loop-helix-PAS protein MOP3|brain and muscle ARNT-like 1|class E basic helix-loop-helix protein 5|member of PAS protein 3|member of PAS superfamily 3
Swissprots	Q99631 O00316 B5ME11 B7WPG7 A2I2N6 O00327 Q8IUT4 D3DQW6 Q4G136 O00315 O00314 O00313 O00317 Q99649 A8K645
Accessions	ABM64205 BAA19936 EAW68503 EAW68504 EAW68505 EAW68506 EAW68507 EAW68508 EAW68509 EAW68510 EAW68511 EAW68512 EAW68513 O00327 AB000812 BAA19935 AB000814 BAA19937 AB000815 BAA19938 AB000816 BAA19939 AF044288 AAC24353 AK095749 BAG53120 AK128317 AK291510 BAF84199 AK315174 BAG37615 BC016674 AAH16674 BC031214 AAH31214 BC041129 AAH41129 BE391243 D89722 BAA19968 EU446463 ABZ91992 JF432385 ADZ15602 U51627 AAC51213 U60415 AAB37248 XM_006718233 XP_006718296 XM_006718234 XP_006718297 XM_011520105 XP_011518407 XM_011520106 XP_011518408 XM_011520107 XP_011518409 XM_011520108 XP_011518410 XM_011520109 XP_011518411 XM_011520110 XP_011518412 XM_011520111 XP_011518413 XM_011520112 XP_011518414 XM_011520113 XP_011518415 NM_001030272 NP_001025443 NM_001030273 NP_001025444 NM_001178 NP_001169 NM_001297719 NP_001284648 NM_001297722 NP_001284651 NM_001297724 NP_001284653
Function	Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00981, ECO:0000269|PubMed:24005054}. Cytoplasm {ECO:0000250|UniProtKB:Q9WTL8}. Nucleus, PML body {ECO:0000250|UniProtKB:Q9WTL8}. Note=Shuttles between the nucleus and the cytoplasm and this nucleocytoplasmic shuttling is essential for the nuclear accumulation of CLOCK, target gene transcription and the degradation of the CLOCK-ARNTL/BMAL1 heterodimer. The sumoylated form localizes in the PML body. Sequestered to the cytoplasm in the presence of ID2. {ECO:0000250|UniProtKB:Q9WTL8}.
Tissue Specificity	Hair follicles (at protein level). Highly expressed in the adult brain, skeletal muscle and heart. {ECO:0000269|PubMed:24005054}.
Top Pathways	Circadian rhythm, Herpes simplex infection, Dopaminergic synapse

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ARNTL-Over-expression-Lysate - LY10870a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ARNTL / BMAL1 Lysate(Denatured) - H00000406-T01 from Acris Antibodies Category Cell Lysate Prices $320.00 Sizes 100 µl

ARNTL overexpression lysate - LY400474 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ARNTL overexpression lysate - LY422246 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

ARNTL overexpression lysate - LY422247 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

ARNTL 293 Cell Lysate - 400483 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ARNTL 293 Cell Lysate - 409689 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ARNTL 293 Cell Lysate - 409688 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

BMAL1 Overexpression Lysate (Denatured) - H00000406-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

BMAL1 Overexpression Lysate (Native) - NBL1-07723 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

BMAL1 Overexpression Lysate (Native) - NBL1-07724 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

BMAL1 Overexpression Lysate (Native) - NBL1-07722 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

BMAL1 (h): 293T Lysate - sc-112447 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

BMAL1 (h2): 293T Lysate - sc-115751 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ARNTL Over-expression Lysate Product - GWB-AE339F from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ARNTL Over-expression Lysate Product - GWB-6E37D9 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

ARNTL Over-expression Lysate Product - GWB-4C0622 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

Panoply™ Human ARNTL Knockdown Stable Cell Line - CSC-DC000965 from Creative biogene Category Cell Line Species Human

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