| Gene Symbol | FUT1 |
|---|---|
| Entrez Gene | 2523 |
| Alt Symbol | H, HH, HSC |
| Species | Human |
| Gene Type | protein-coding |
| Description | fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group) |
| Other Description | 2-alpha-L-fucosyltransferase|GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 1|alpha (1,2) fucosyltransferase|alpha(1,2) fucosyltransferase 1|alpha(1,2)FT 1|blood group H alpha 2-fucosyltransferase|fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase)|galactoside 2-alpha-L-fucosyltransferase 1 |
| Swissprots | O14506 O14505 O14507 P19526 |
| Accessions | AAL57863 AAT42242 AAV51818 AAW82437 AAY96648 AAZ81507 ABC59307 ABU75130 ABU75131 ABU75132 ACN41952 ACT82507 ADP20182 ADX86835 AEA76422 AFO67890 AFS30924 AGU16805 AGY31283 AHJ09661 AII25874 AIT68783 AIU94775 AIU94776 BAA20556 BAA20557 BAA20558 BAA20559 BAA20560 BAA28952 CAA93435 CAC81751 CAQ56300 CAQ81977 EAW52399 P19526 BC074732 AAH74732 CN359119 D87935 D87936 D87937 D87938 D87939 D87940 D87941 M35531 AAA52639 XM_006723127 XP_006723190 NM_000148 NP_000139 |
| Function | Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble A and B antigen synthesis pathway. H and Se enzymes fucosylate the same acceptor substrates but exhibit different Km values. |
| Subcellular Location | Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Membrane-bound form in trans cisternae of Golgi. |
| Top Pathways | Glycosphingolipid biosynthesis - globo series, Glycosphingolipid biosynthesis - lacto and neolacto series |