MEFV

Gene Symbol	MEFV
Entrez Gene	4210
Alt Symbol	FMF, MEF, TRIM20
Species	Human
Gene Type	protein-coding
Description	Mediterranean fever
Other Description	marenostrin|pyrin
Swissprots	D3DUC0 Q96PN5 Q3MJ84 F5H0Q3 O15553 Q96PN4
Accessions	AAD26152 AAK97223 AAK97224 ABQ57362 BAM20997 CAA05906 EAW85382 EAW85383 O15553 AF018080 AAB70557 AK298660 BAG60828 BC101511 AAI01512 BC101537 AAI01538 FJ785717 ACV82585 FJ785718 ACV82586 FJ785719 ACV82587 FJ785720 ACV82588 FJ785721 ACV82589 FJ785722 ACV82590 Y14441 CAA74793 NM_000243 NP_000234 NM_001198536 NP_001185465
Function	Involved in innate immunity and the inflammatory response. Interacts with several components of the inflammasome complex, a large oligomeric structure which recruits and activates CASP1 and ultimately induces maturation of cytokines such as IL1B. However, the exact role of MEFV in the inflammatory pathway is uncertain as contradictory effects on IL1B processing have been reported in different experimental systems. Has been shown to activate IL1B production (PubMed:16037825). Has also been shown to inhibit IL1B production (PubMed:16785446, PubMed:17431422). Also required for PSTPIP1-induced PYCARD oligomerization and for formation of pyroptosomes, large supramolecular structures composed of oligomerized PYCARD dimers which form prior to inflammatory apoptosis. Can reduce PYCARD-induced apoptosis. Recruits PSTPIP1 to pyroptosomes, and required for PSTPIP1 oligomerization. {ECO:0000269|PubMed:10807793, ECO:0000269|PubMed:11468188, ECO:0000269|PubMed:16037825, ECO:0000269|PubMed:16785446,
Subcellular Location	Isoform 1: Cytoplasm, cytoskeleton. Cell projection, ruffle. Cell projection, lamellipodium. Nucleus. Note=Associated with microtubules and with the filamentous actin of perinuclear filaments and peripheral lamellar ruffles. In pre- apoptotic cells, colocalizes with PYCARD/ASC in large specks (pyroptosomes). In migrating monocytes, strongly polarized at the leading edge of the cell where it colocalizes with polymerizing actin and PYCARD/ASC.
Tissue Specificity	Expressed in peripheral blood leukocytes, particularly in mature granulocytes and to a lesser extent in monocytes but not in lymphocytes. Detected in spleen, lung and muscle, probably as a result of leukocyte infiltration in these tissues. Not expressed in thymus, prostate, testis, ovary, small intestine, colon, heart, brain, placenta, liver, kidney, pancreas. Expression detected in several myeloid leukemic, colon cancer, and prostate cancer cell lines. {ECO:0000269|PubMed:10666224, ECO:0000269|PubMed:10807793, ECO:0000269|PubMed:11115844}.
Top Pathways	NOD-like receptor signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human MEFV protein fragment - ab158876 from Abcam Category Protein Source Wheat germ Species Human

MEFV peptide (428-440) - ab45796 from Abcam Category Peptide Species Human

Pyrin / MEFV / MEF Antibody Blocking Peptide - LS-E6779 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Pyrin / MEFV / MEF Antibody Blocking Peptide - LS-E25926 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Pyrin / MEFV / MEF Antibody Blocking Peptide - LS-E13616 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MEFV Partial Recombinant Protein - H00004210-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

MEFV-AntibodyCenter-Blocking-peptide - BP19672c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

MEFV blocking peptide - GTX89483-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human

MEFV Immunizing peptide - orb16828 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

MEFV Peptide - AC21-0755-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Pyrin - H00004210-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Pyrin - H00004210-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

MEFV Peptide - 45-880P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

MEFV fusion protein - ag18000 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human Pyrin(MEFV) - CSB-YP013675HU CSB-EP013675HU CSB-BP013675HU CSB-MP013675HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

MEFV, Peptide - MBS425478 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

MEFV Peptide, Human - M34GP09389H from Creative Peptides Category Peptide Source Synthetic. Species Human

Pyrin (MEFV), Recombinant Protein - MBS1211393 from MyBioSource Category Protein Prices $1,610.00, $1,610.00, $1,840.00, $1,840.00, $2,720.00, $2,720.00, $3,175.00, $3,175.00, $3,175.00, $5,375.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 50 µg (Mammalian-Cell), 500 µg (Yeast), 1 mg (E-Coli), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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