Gene Symbol | PPFIA2 |
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Entrez Gene | 8499 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2 |
Other Description | liprin-alpha-2 |
Swissprots | E7ETG6 F8VP68 B7Z2A6 E7ERB8 B3KXA0 Q2M3G8 B7ZKZ5 B7Z663 B3KVT5 B7Z3U9 O75334 |
Accessions | EAW97374 EAW97375 EAW97376 EAW97377 O75334 AB210009 BAE06091 AF034799 AAC26100 AK123372 BAG53897 AK126971 BAG54412 AK294505 BAH11792 AK296380 BAH12335 AK297372 BAH12564 AK299853 BAH13149 AK302658 BAH13771 AK307524 AL157453 AL713132 AW014561 AW304872 BC104912 AAI04913 BC143485 AAI43486 BM661844 BM689808 BQ027545 BU568524 CB051855 DA329958 DA368637 DA499362 DA533482 DA687865 DB083201 DC321269 DC322478 EL947964 XM_006719655 XP_006719718 XM_006719656 XP_006719719 XM_006719657 XP_006719720 XM_006719658 XP_006719721 XM_006719659 XP_006719722 XM_006719660 XP_006719723 XM_006719661 XP_006719724 XM_006719662 XP_006719725 XM_006719663 XP_006719726 XM_006719664 XP_006719727 XM_006719665 XP_006719728 XM_006719666 XP_006719729 XM_006719667 XP_006719730 XM_006719668 XP_006719731 XM_006719669 XP_006719732 XM_006719670 XP_006719733 XM_011538899 XP_011537201 XM_011538900 XP_011537202 XM_011538901 XP_011537203 XM_011538902 XP_011537204 XM_011538903 XP_011537205 XM_011538904 XP_011537206 XM_011538905 XP_011537207 XM_011538906 XP_011537208 XM_011538907 XP_011537209 NM_001220473 NP_001207402 NM_001220474 NP_001207403 NM_001220475 NP_001207404 NM_001220476 NP_001207405 NM_001220477 NP_001207406 NM_001220478 NP_001207407 NM_001220479 NP_001207408 NM_001220480 NP_001207409 NM_001282536 NP_001269465 NM_003625 NP_003616 |
Function | Alters PTPRF cellular localization and induces PTPRF clustering. May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates. {ECO:0000269|PubMed:9624153}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:9624153}. Cell surface {ECO:0000269|PubMed:9624153}. Note=Colocalizes with PTPRF at the cell surface. |
Tissue Specificity | Expressed only in brain. {ECO:0000269|PubMed:9624153}. |
Liprin α2 CRISPR/Cas9 KO Plasmid (h) - sc-417837 from Santa Cruz Biotechnology
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Liprin α2 HDR Plasmid (h) - sc-417837-HDR from Santa Cruz Biotechnology
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Liprin α2 Double Nickase Plasmid (h) - sc-417837-NIC from Santa Cruz Biotechnology
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Liprin α2 Double Nickase Plasmid (h2) - sc-417837-NIC-2 from Santa Cruz Biotechnology
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Liprin α2 CRISPR Activation Plasmid (h) - sc-417837-ACT from Santa Cruz Biotechnology
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Liprin α2 CRISPR Activation Plasmid (h2) - sc-417837-ACT-2 from Santa Cruz Biotechnology
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Liprin α2 Lentiviral Activation Particles (h) - sc-417837-LAC from Santa Cruz Biotechnology
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Liprin α2 Lentiviral Activation Particles (h2) - sc-417837-LAC-2 from Santa Cruz Biotechnology
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Liprin α2 siRNA (h) - sc-72332 from Santa Cruz Biotechnology
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Liprin α2 shRNA Plasmid (h) - sc-72332-SH from Santa Cruz Biotechnology
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Liprin α2 shRNA (h) Lentiviral Particles - sc-72332-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU023301 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0468 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0466 from Sigma-Aldrich
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MISSION® Human Phosphatase - SIHP0467 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN17213 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17213 from Sigma-Aldrich
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PPFIA2 siRNA (Human) - CRH5573 from Cohesion Biosciences
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shRNA set against Human PPFIA2 (NM_003625.3) - SHH380484 from Creative biogene
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Human PPFIA2 siRNA - orb266075 from Biorbyt
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PPFIA2 shRNA Plasmid (Human) - CHH5573 from Cohesion Biosciences
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PPFIA2 miRNA 3'UTR clone - MiUTR3H-05707 from Creative biogene
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