| Gene Symbol |
HMMR
|
| Entrez Gene |
3161
|
| Alt Symbol |
CD168, IHABP, RHAMM
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
hyaluronan-mediated motility receptor (RHAMM)
|
| Other Description |
hyaluronan mediated motility receptor|intracellular hyaluronic acid-binding protein|receptor for hyaluronan-mediated motility
|
| Swissprots |
Q32N02 Q92767 E9PCS0 B4E114 O75330 D3DQK9 D3DQL0 A8K3G2
|
| Accessions |
ACD35245 EAW61521 EAW61522 EAW61523 EAW61524 EAW61525 O75330 AF032862 AAC32548 AK290577 BAF83266 AK302975 BAG64118 AK303616 BAG64626 AK313603 AW629232 AY623426 BC017793 AAH17793 BC030505 AAH30505 BC033568 BC057235 AAH57235 BC070281 AAH70281 BC107869 BC108904 AAI08905 BC108905 DB091289 U29343 AAC52049 NM_001142556 NP_001136028 NM_001142557 NP_001136029 NM_012484 NP_036616 NM_012485 NP_036617
|
| Function |
Involved in cell motility. When hyaluronan binds to HMMR, the phosphorylation of a number of proteins, including PTK2/FAK1 occurs. May also be involved in cellular transformation and metastasis formation, and in regulating extracellular- regulated kinase (ERK) activity.
|
| Subcellular Location |
Cell surface. Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Expressed in breast cancer cell lines and in normal breast tissue.
|
| Top Pathways |
ECM-receptor interaction
|
![Western Blot: CD168 Overexpression Lysate (Adult Normal) [NBL1-11623] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CD168.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9371_CD168%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-11623-img0002.jpg)
![Western Blot: CD168 Lysate [NBL1-11622] - Western Blot experiments. Left-Control; Right -Over-expression Lysate for HMMR](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2703_CD168%2520Lysate-Western%2520Blot-NBL1-11622-img0001.jpg)