| Gene Symbol |
GPR3
|
| Entrez Gene |
2827
|
| Alt Symbol |
ACCA
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
G protein-coupled receptor 3
|
| Other Description |
ACCA orphan receptor|G-protein coupled receptor 3|adenylate cyclase constitutive activator
|
| Swissprots |
A8K570 P46089
|
| Accessions |
AAA64594 AAA73560 AAB60402 CAA58787 CAC18517 EAX07754 P46089 AK291185 BAF83874 AK314868 BAG37383 BC032702 AAH32702 BQ882813 DQ890832 ABM81758 DQ893987 ABM84913 HQ709189 ADZ17396 NM_005281 NP_005272
|
| Function |
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Has a potential role in modulating a number of brain functions, including behavioral responses to stress (By similarity), amyloid-beta peptide generation in neurons and neurite outgrowth (By similarity). Maintains also meiotic arrest in oocytes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein.
|
| Tissue Specificity |
Expressed predominantly in the central nervous system, and at low levels in the lung, kidney, testis, ovary and eye. Highly expressed in regions of the brain implicated in the Alzheimer disease.
|