| Gene Symbol |
RGS4
|
| Entrez Gene |
5999
|
| Alt Symbol |
RGP4, SCZD9
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
regulator of G-protein signaling 4
|
| Other Description |
schizophrenia disorder 9
|
| Swissprots |
B1APZ3 A7XA56 A7YVV7 A7XA59 A7XA58 P49798
|
| Accessions |
EAW90727 EAW90728 EAW90729 P49798 AB209019 BAD92256 AF493928 AAM12642 AK093959 AK096204 AK295540 BAG58449 AK296240 BAG58958 AK300832 BAG62483 AK312250 BAG35182 AL137433 BC000737 AAH00737 BC051869 AAH51869 BI547160 BT007025 AAP35671 DA253378 DA660018 DA660695 DC318279 DC334933 DQ346662 ABC94590 DQ346663 ABC94591 DQ346664 ABC94592 EF054877 ABL74968 U27768 AAC50395 NM_001102445 NP_001095915 NM_001113380 NP_001106851 NM_001113381 NP_001106852 NM_005613 NP_005604
|
| Function |
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein.
|
| Tissue Specificity |
Expressed in brain and heart. Expressed in brain at protein level. Expressed in prefontal and visual cortex. Isoform 4 and isoform 5 are expressed ubiquitously. Isoform 1, isoform 2 and isoform 3 are not expressed in the cerebellum. {ECO:0000269|PubMed:17707117}.
|
![Western Blot: RGS4 Overexpression Lysate (Adult Normal) [NBL1-15334] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RGS4.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/756_RGS4%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15334-img0002.jpg)