Gene Symbol | METTL1 |
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Entrez Gene | 4234 |
Alt Symbol | C12orf1, TRM8, TRMT8, YDL201w |
Species | Human |
Gene Type | protein-coding |
Description | methyltransferase like 1 |
Other Description | D1075-like gene product|methyltransferase-like 1|methyltransferase-like protein 1|tRNA (guanine(46)-N(7))-methyltransferase|tRNA (guanine-N(7)-)-methyltransferase|tRNA(m7G46)-methyltransferase |
Swissprots | H7BXF2 Q14105 Q53FS9 B2RBX1 Q9UBP6 |
Accessions | CAA77238 EAW97066 EAW97069 EAW97070 EAW97071 Q9UBP6 AA317248 AI168455 AK223202 BAD96922 AK314851 BAG37368 BC000550 AAH00550 BG420288 BQ651940 W56190 X96698 CAA65470 Y18643 CAA77239 XM_005268873 XP_005268930 NM_005371 NP_005362 NM_023033 NP_075422 NM_023032 |
Function | Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000269|PubMed:12403464}. |
Subcellular Location | Nucleus {ECO:0000255|HAMAP-Rule:MF_03055, ECO:0000269|PubMed:15861136}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10329009}. |
METTL1 CRISPR/Cas9 KO Plasmid (h) - sc-409181 from Santa Cruz Biotechnology
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METTL1 HDR Plasmid (h) - sc-409181-HDR from Santa Cruz Biotechnology
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METTL1 Double Nickase Plasmid (h) - sc-409181-NIC from Santa Cruz Biotechnology
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METTL1 Double Nickase Plasmid (h2) - sc-409181-NIC-2 from Santa Cruz Biotechnology
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METTL1 CRISPR Activation Plasmid (h) - sc-409181-ACT from Santa Cruz Biotechnology
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METTL1 CRISPR Activation Plasmid (h2) - sc-409181-ACT-2 from Santa Cruz Biotechnology
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METTL1 Lentiviral Activation Particles (h) - sc-409181-LAC from Santa Cruz Biotechnology
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METTL1 Lentiviral Activation Particles (h2) - sc-409181-LAC-2 from Santa Cruz Biotechnology
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METTL1 siRNA (h) - sc-96124 from Santa Cruz Biotechnology
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METTL1 shRNA Plasmid (h) - sc-96124-SH from Santa Cruz Biotechnology
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METTL1 shRNA (h) Lentiviral Particles - sc-96124-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU076851 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN13224 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13224 from Sigma-Aldrich
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METTL1 siRNA (Human) - CRH2877 from Cohesion Biosciences
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shRNA set against Human METTL1 (NM_005371.5) - SHH340623 from Creative biogene
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shRNA set against Human METTL1(NM_005371.5) - SHH185627 from Creative biogene
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shRNA set against Human METTL1(NM_023033.3) - SHH185645 from Creative biogene
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Human METTL1 siRNA - orb263379 from Biorbyt
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METTL1 shRNA Plasmid (Human) - CHH2877 from Cohesion Biosciences
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METTL1 miRNA 3'UTR clone - MiUTR1H-06221 from Creative biogene
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METTL1 miRNA 3'UTR clone - MiUTR1H-06222 from Creative biogene
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