| Gene Symbol |
ncapd2
|
| Entrez Gene |
398080
|
| Alt Symbol |
pEg7
|
| Species |
Xenopus
|
| Gene Type |
protein-coding
|
| Description |
non-SMC condensin I complex, subunit D2
|
| Other Description |
13S condensin XCAP-D2 subunit|chromosome assembly protein XCAP-D2|chromosome condensation-related SMC-associated protein 1|chromosome-associated protein D2|condensin complex subunit 1|eg7
|
| Swissprots |
Q9YGS5 Q9YHY6
|
| Accessions |
Q9YHY6 AF067969 AAC64359 AF072717 AAD15962 BC170462 AAI70462 NM_001088371 NP_001081840
|
| Function |
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. {ECO:0000269|PubMed:10428035, ECO:0000269|PubMed:9774278, ECO:0000269|PubMed:9852142}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:9852142}. Cytoplasm {ECO:0000269|PubMed:9852142}. Chromosome {ECO:0000269|PubMed:9852142}. Note=In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
|