| Gene Symbol |
Ugt2a3
|
| Entrez Gene |
72094
|
| Alt Symbol |
2010321J07Rik
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
UDP glucuronosyltransferase 2 family, polypeptide A3
|
| Other Description |
UDP-glucuronosyltransferase 2A3|UDPGT 2A3
|
| Swissprots |
Q9D811 Q8R129 Q8BWQ1
|
| Accessions |
EDL37977 Q8BWQ1 AK008601 BAB25770 AK050327 BAC34191 BC025795 AAH25795 BY460703 NM_028094 NP_082370
|
| Function |
UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Highly expressed in liver, with lower levels in duodenum and jejunum. {ECO:0000269|PubMed:17050650}.
|
| Top Pathways |
Chemical carcinogenesis, Steroid hormone biosynthesis, Drug metabolism - other enzymes, Drug metabolism - cytochrome P450, Metabolism of xenobiotics by cytochrome P450
|