| Gene Symbol | CLSTN1 |
|---|---|
| Entrez Gene | 22883 |
| Alt Symbol | ALC-ALPHA, CDHR12, CST-1, CSTN1, PIK3CD, XB31alpha, alcalpha1, alcalpha2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | calsyntenin 1 |
| Other Description | alcadein-alpha|alzheimer-related cadherin-like protein|cadherin-related family member 12|calsyntenin-1|non-classical cadherin XB31alpha |
| Swissprots | Q71MN0 Q5UE58 Q8N4K9 Q5SR52 A8K183 O94985 |
| Accessions | EAW71629 EAW71630 O94985 AB020718 BAA74934 AF438482 AAQ04552 AK000605 AK001591 BAG50945 AK056820 BAG51814 AK225500 AK289798 BAF82487 AK304813 BAG65563 AY545556 AY753301 AAV30551 BC033902 AAH33902 BI335759 CB132727 DQ891263 ABM82189 DQ894450 ABM85376 NM_001009566 NP_001009566 NM_001302883 NP_001289812 NM_014944 NP_055759 |
| Function | Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2- mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP. The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1- binding. May modulate calcium-mediated postsynaptic signals (By similarity). {ECO:0000250}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:17332754}; Single-pass type I membrane protein {ECO:0000269|PubMed:17332754}. Golgi apparatus membrane {ECO:0000269|PubMed:17332754}. Cell projection {ECO:0000269|PubMed:17332754}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Nucleus {ECO:0000269|PubMed:17332754}. Note=Neurite tips. Localized in the postsynaptic membrane of both excitatory and inhibitory synapses (By similarity). The AlcICD fragment is translocated to the nucleus upon interaction with APBB1. {ECO:0000250}. |
| Tissue Specificity | Expressed in the brain and, a lower level, in the heart, skeletal muscle, kidney and placenta. Accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques (at protein level). {ECO:0000269|PubMed:12498782, ECO:0000269|PubMed:12972431}. |
Human PIK3Cd ELISA Kit - abx152743 from Abbexa
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Calsyntenin-1 (CLSTN1), Human, ELISA Kit - E01C1816 from ARP American Research Products
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Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform, PIK3CD, Human, ELISA Kit - E14309h from ARP American Research Products
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Phosphoinositide-3-Kinase Catalytic Delta Polypeptide, PIK3C_, Human, ELISA Kit - E-EL-H1019 from ARP American Research Products
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Phosphoinositide-3-Kinase Catalytic Delta Polypeptide, PIK3C_, Rabbit, ELISA Kit - E-EL-RB2037 from ARP American Research Products
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Phosphoinositide-3-Kinase Catalytic Delta Polypeptide, PIK3C_, Chicken, ELISA Kit - E-EL-Ch1099 from ARP American Research Products
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Phosphoinositide-3-Kinase Catalytic Delta Polypeptide, PIK3C_, Porcine, ELISA Kit - E-EL-P0810 from ARP American Research Products
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Phosphoinositide-3-Kinase Catalytic Delta Polypeptide, PIK3C_, Guinea Pig, ELISA Kit - E-EL-GP0390 from ARP American Research Products
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Phosphoinositide-3-Kinase Catalytic Delta Polypeptide, PIK3C_, Monkey, ELISA Kit - E-EL-MK1931 from ARP American Research Products
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Custom Human Calsyntenin-1 ELISA - ELH-CLSTN1 from RayBiotech
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Calsyntenin 1 (CLSTN1), ELISA Kit - MBS9312286 from MyBioSource
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Calsyntenin 1 (CLSTN1), ELISA Kit - MBS7231040 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7237152 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7202617 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7207506 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7246449 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7240575 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7244174 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7244194 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7207095 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7202768 from MyBioSource
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Calsyntenin-1 (CLSTN1), ELISA Kit - MBS7229393 from MyBioSource
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Phosphoinositide-3-Kinase Catalytic Delta Polypeptide (PIK3Cd), Human, ELISA Kit - DL-PIK3Cd-Hu from ARP American Research Products
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Human CLSTN1(Calsyntenin 1) ELISA Kit - E-EL-H2478 from Elabscience
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Human PIK3Cd ELISA Kit - abx572476 from Abbexa
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