| Gene Symbol |
ATF7IP
|
| Entrez Gene |
55729
|
| Alt Symbol |
AM, ATF-IP, MCAF, MCAF1, p621
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
activating transcription factor 7 interacting protein
|
| Other Description |
ATF-interacting protein|ATF7-interacting protein|ATFa-associated modulator|MBD1-containing chromatin-associated factor 1|activating transcription factor 7-interacting protein 1
|
| Swissprots |
Q6P3T3 G3V1U0 Q86XW5 Q6VMQ6 Q9NWC2 Q4G0T9 F5GX74 Q9Y4X8 Q9NVJ9
|
| Accessions |
EAW96314 EAW96315 EAW96316 EAW96317 EAW96318 EAW96319 EAW96320 Q6VMQ6 AF425650 AAO91864 AJ242978 CAB45135 AK001001 AK001550 BAA91751 AK025060 AK027575 BAG51349 AK074868 BAG52020 AK125103 AK299320 BAG61328 AK304184 BAG65064 AK308062 AY337596 AAQ92978 BC037312 AAH37312 BC053625 BC063855 AAH63855 BX648096 DA194386 DC377662 XM_005253424 XP_005253481 XM_006719108 XP_006719171 XM_006719109 XP_006719172 XM_011520754 XP_011519056 XM_011520755 XP_011519057 XM_011520756 XP_011519058 XM_011520757 XP_011519059 XM_011520758 XP_011519060 XM_011520759 XP_011519061 NM_001286514 NP_001273443 NM_001286515 NP_001273444 NM_018179 NP_060649 NM_181352 NP_851997
|
| Function |
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. Required to stimulate histone methyltransferase activity of SETDB1 and facilitate the conversion of dimethylated to trimethylated H3 'Lys-9' (H3K9me3). The complex formed with MBD1 and SETDB1 represses transcription and couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3). Facilitates telomerase TERT and TERC gene expression by SP1 in cancer cells. {ECO:0000269|PubMed:12665582, ECO:0000269|PubMed:14536086, ECO:0000269|PubMed:19106100}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19106100}.
|
| Tissue Specificity |
Detected at low levels in breast, lung and stomach; highly up-regulated in the corresponding cancerous tissues (at protein level). {ECO:0000269|PubMed:19106100}.
|